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Histoire d’eau : le lithium et le sodium, les lésions dangereuses
- Source :
- Annales de Biologie Clinique, Annales de Biologie Clinique, 2020, ⟨10.1684/abc.2020.1570⟩
- Publication Year :
- 2020
- Publisher :
- John Libbey Eurotext, 2020.
-
Abstract
- International audience; Nephrogenic diabetes insipidus due to the inability of the kidneys to concentrate urine is frequently observed during lithium therapy. Lithium concentrates into principal cells in collecting ducts in the kidney and downregulates aquaporin 2 expression, which reduces renal reabsorption of water. This disease is characterized by polyuria - polydipsia leading to intracellular dehydration and hypernatremia. Water deprivation test is performed to confirm insipidus diabetes. The desmopressin permits to distinguish nephrogenic from cranial insipidus diabetes. We report the case of a 64 years old women who presented with global dehydration and severe hypernatremia. Four years ago, she was hospitalized for nephrogenic diabetes insipidus related to a self-induced lithium intoxication. Persistent nephrogenic insipidus diabetes after cessation of lithium therapy are described in literature, and this hypothesis may be consistent with this case report.
- Subjects :
- medicine.medical_specialty
Bipolar Disorder
endocrine system diseases
Lithium (medication)
[SDV]Life Sciences [q-bio]
diuretic
Urology
Diabetes Insipidus, Nephrogenic
urologic and male genital diseases
03 medical and health sciences
0302 clinical medicine
nephrogenic diabetes insipidus
Polyuria
Diabetes mellitus
medicine
Humans
030212 general & internal medicine
Desmopressin
Dehydration
hypernatremia
business.industry
Sodium
Water Intoxication
Water
General Medicine
Middle Aged
medicine.disease
Nephrogenic diabetes insipidus
female genital diseases and pregnancy complications
3. Good health
[SDV] Life Sciences [q-bio]
lithium
Aquaporin 2
Lithium Compounds
Female
Hypernatremia
medicine.symptom
business
Polydipsia
hormones, hormone substitutes, and hormone antagonists
030217 neurology & neurosurgery
medicine.drug
Subjects
Details
- ISSN :
- 00033898
- Volume :
- 78
- Database :
- OpenAIRE
- Journal :
- Annales de Biologie Clinique
- Accession number :
- edsair.doi.dedup.....c31b12857114e16d8a788d6bd39dacc7