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Therapeutic apheresis exchange in two patients with prolidase deficiency
- Source :
- British Journal of Dermatology. 147:1237-1240
- Publication Year :
- 2002
- Publisher :
- Oxford University Press (OUP), 2002.
-
Abstract
- Summary BackgroundProlidase deficiency is a rare genetic disorder for which a cure has not yet been found. Objectives To assess the effectiveness of apheresis exchange as a new therapeutic approach. Methods Apheresis exchanges were repeated monthly for four consecutive months, in parallel, on two patients, replacing prolidase-deficient red blood cells with normal filtered cells. Prolidase activity and urinary dipeptides were determined at regular intervals. Results The constant presence of active prolidase inside cells allowed a continuous, although partial, degradation of imidodipeptides, with a concomitant improvement of skin ulceration. Conclusions Apheresis exchange could be a reasonable way of obtaining a clinical improvement in these patients.
- Subjects :
- Adult
Male
Dipeptidases
medicine.medical_specialty
Erythrocytes
Urinary system
Dermatology
Gastroenterology
Therapeutic approach
Internal medicine
medicine
Humans
Therapeutic apheresis
Prolidase deficiency
business.industry
Leg Ulcer
Electrophoresis, Capillary
Middle Aged
medicine.disease
Surgery
Red blood cell
Apheresis
medicine.anatomical_structure
Concomitant
Blood Component Removal
Female
X-Pro dipeptidase
business
Follow-Up Studies
Subjects
Details
- ISSN :
- 13652133 and 00070963
- Volume :
- 147
- Database :
- OpenAIRE
- Journal :
- British Journal of Dermatology
- Accession number :
- edsair.doi.dedup.....c31d75da8eb474a33cb9c1d8fc467e68