Development of Fluorinated Peptoid-Based Histone Deacetylase (HDAC) Inhibitors for Therapy-Resistant Acute Leukemia

Authors :: Nina Reßing
Julian Schliehe-Diecks
Paris R. Watson
Melf Sönnichsen
Abigail D. Cragin
Andrea Schöler
Jing Yang
Linda Schäker-Hübner
Arndt Borkhardt
David W. Christianson
Sanil Bhatia
Finn K. Hansen
Source :: Journal of medicinal chemistry. 65(22)
Publication Year :: 2023
Abstract: Using a microwave-assisted protocol, we synthesized 16 peptoid-capped HDAC inhibitors (HDACi) with fluorinated linkers and identified two hit compounds. In biochemical and cellular assays

Subjects :: Histone Deacetylase Inhibitors
Peptoids
Leukemia, Myeloid, Acute
Cell Line, Tumor
Drug Discovery
Molecular Medicine
Humans
Antineoplastic Agents
Histone Deacetylase 1
Histone Deacetylase 6
Decitabine
Hydroxamic Acids

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