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A surface-adaptive nanocarrier to prolong circulation time and enhance cellular uptake
- Source :
- Chemical Communications. 51:14985-14988
- Publication Year :
- 2015
- Publisher :
- Royal Society of Chemistry (RSC), 2015.
-
Abstract
- Based on the protonation/deprotonation of poly(β-amino ester) (PAE), mixed-shell micelles (MSMs) with adaptive surfaces could rapidly and reversibly change surface properties to prolong circulation time in blood (pH 7.4) and enhance cellular uptake at tumor sites (pH 6.5).
- Subjects :
- Time Factors
Cell Survival
Polymers
Surface Properties
Mice, Nude
Protonation
Micelle
Catalysis
Mice
Liver Neoplasms, Experimental
Deprotonation
Materials Chemistry
medicine
Animals
Humans
Tissue Distribution
Doxorubicin
Micelles
Cell survival
Drug Carriers
Mice, Inbred BALB C
Antibiotics, Antineoplastic
Molecular Structure
Chemistry
Metals and Alloys
Hep G2 Cells
General Chemistry
Hydrogen-Ion Concentration
Nanostructures
Surfaces, Coatings and Films
Electronic, Optical and Magnetic Materials
Biochemistry
Ceramics and Composites
Biophysics
Circulation time
Protons
Nanocarriers
Drug carrier
medicine.drug
Subjects
Details
- ISSN :
- 1364548X and 13597345
- Volume :
- 51
- Database :
- OpenAIRE
- Journal :
- Chemical Communications
- Accession number :
- edsair.doi.dedup.....c32a76d827fb3b0b924ab0eddcdf32d5