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The effects of prenatal androgen exposure on cardiac function and tolerance to ischemia/reperfusion injury in male and female rats during adulthood
- Source :
- Life Sciences. 229:251-260
- Publication Year :
- 2019
- Publisher :
- Elsevier BV, 2019.
-
Abstract
- Cardiovascular diseases may originate from suboptimal intrauterine environments. We aimed to examine the effects of prenatal androgen exposure (PAE) on heart basal hemodynamic parameters and tolerance to ischemia/reperfusion (I/R) injury, in PAE adult females and males.Pregnant Wistar rats in the experimental group (n = 8) received 5 mg of testosterone (s.c. injection) on the 20th day of pregnancy, while controls received solvent. The hearts of adult female and male offspring were isolated and perfused in a Langendorff apparatus, values of left ventricular systolic pressure(LVSP), left ventricular developed pressure(LVDP), rate pressure product(RPP) and peak rates of positive and negative changes in left ventricular pressure(±dp/dt) were recorded using a power lab system.At baseline, PAE adult males demonstrated significant higher values of LVSP, LVDP, RPP and ± dp/dt, compared to controls and PAE adult females (p 0.05), while PAE adult females showed no significant differences compared to controls. In PAE adult males, LVSP, LVDP, RPP and ± dp/dt had significant decreasing trends per phases after I/R, compared to their controls and PAE females, while these decreasing trends were not statistically significant in PAE adult female rats vs. their controls.The impact of prenatal androgen exposure on adulthood cardiac function and tolerance to I/R is gender dependent, which may be partly explained by different cardiac effects of hyperandrogenism in males versus females. After prenatal androgen exposure, the baseline hemodynamic parameters of the hearts of adult males are increased; although they had less tolerance to I/R, findings however not observed in females.
- Subjects :
- Male
0301 basic medicine
Cardiac function curve
medicine.medical_specialty
animal structures
Offspring
medicine.drug_class
Hemodynamics
Blood Pressure
Myocardial Reperfusion Injury
030226 pharmacology & pharmacy
General Biochemistry, Genetics and Molecular Biology
03 medical and health sciences
0302 clinical medicine
Pregnancy
Internal medicine
medicine
Animals
Rats, Wistar
General Pharmacology, Toxicology and Pharmaceutics
Testosterone
business.industry
Heart
Drug Tolerance
General Medicine
Androgen
medicine.disease
Rats
030104 developmental biology
Endocrinology
Rate pressure product
Prenatal Exposure Delayed Effects
Androgens
Ventricular pressure
Female
business
Reperfusion injury
Subjects
Details
- ISSN :
- 00243205
- Volume :
- 229
- Database :
- OpenAIRE
- Journal :
- Life Sciences
- Accession number :
- edsair.doi.dedup.....c32f4bd24d1fc9dfc6c2884067f6aded