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Anti-thyroid peroxidase antibodies are associated with the absence of distant metastases in patients with newly diagnosed breast cancer
- Publication Year :
- 2012
-
Abstract
- The presence of thyroid peroxidase antibodies (TPOab) are reported to be associated with improved outcome among breast cancer patients. We evaluated the correlation between TPOab and diagnostic parameters among newly diagnosed breast cancer patients.Three hundred and fourteen newly diagnosed patients with breast cancer, diagnosed and treated in Bethesda Essen between January 2002 and June 2006, were included in this study; 258 (82.2%) without TPOab (≤100 IU/mL) and 56 (17.8%) with TPOab (>100 IU/mL). Blood analysis was performed to measure serum levels of carcinoembryonic antigen (CEA), cancer antigen 15-3 (CA-15-3), free triiodothyronine (fT3), free thyroxine (fT4), thyroid-stimulating hormone (TSH) and TPOab by radioimmunoassay. Data regarding age, tumor size, grading, TNM classification, receptor status, lymph node, and distant metastases were collected and analyzed from patient reports. Statistics were performed using Pearson’s χThere were no incidences of distant metastasis among 56 patients with TPOab, whereas 17 (6.6%) of 258 cases without TPOab displayed distant metastases (p=0.04). Logistic regression showed an inverse association of TPOab with CA-15-3 and CEA levels (pTPOab occurrence is associated with significantly lower frequency of distant metastases in breast cancer. TPOab level inversely correlates with the conventional tumor markers CA-15-3 and CEA.
- Subjects :
- medicine.medical_specialty
Antibodies, Neoplasm
Clinical Biochemistry
Medizin
Breast Neoplasms
Logistic regression
Iodide Peroxidase
Gastroenterology
Breast cancer
Carcinoembryonic antigen
Thyroid peroxidase
Internal medicine
Biomarkers, Tumor
medicine
Humans
Neoplasm Metastasis
Grading (tumors)
Lymph node
biology
business.industry
Biochemistry (medical)
Thyroid
General Medicine
Middle Aged
medicine.disease
Anti-thyroid autoantibodies
medicine.anatomical_structure
biology.protein
business
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....c3305860d149b2e0293720953e6e34be