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Evaluation of single nucleotide polymorphisms in 6 candidate genes and carotid intima-media thickness in community-dwelling residents
- Source :
- PLoS ONE, PLoS ONE, Vol 15, Iss 3, p e0230715 (2020)
- Publication Year :
- 2020
- Publisher :
- Public Library of Science (PLoS), 2020.
-
Abstract
- Evidence suggests the existence of association between a large panel of modifiable biomarkers representing inflammation, coagulation, paraoxonase, and endothelial activation pathways and carotid atherosclerosis. Thus, this study investigated whether CRP, FGA, FGB, FGG, PON1, and EDNRA gene variants affected plasma hs-CRP, fibrinogen levels, and thickness of carotid intima media thickness (IMT). Nineteen single-nucleotide polymorphisms of CRP, FGA, FGB, FGG, PON1, and EDNRA genes were examined in 480 participants from 160 families. Carotid IMT was measured by ultrasound. Generalized linear models with generalized estimating equation were utilized to consider the dependence of subjects within families. In the recessive model, homozygotes for the minor alleles of rs1800789, rs1800790 and rs4220 SNPs in FGB gene indicated a reduced risk of IMT (Exp. β = 0.89, 0.89, 0.88), which remained significant after adjustment for confounding factors. Significant interaction effects between CRP SNP rs1130864 and rs3093059 and gender for IMT were observed with a significant association in men only. Men carrying minor-minor genotype of CRP SNP rs1130864 and rs3093059 had 0.70- and 0.78-fold lower IMT than men carrying minor-major/major-major genotype. We also observed that the interaction of CRP SNP rs1130864 and rs3093059 with obesity on IMT, hs-CRP and fibrinogen levels. These results support the hypothesis that inflammatory genes are involved in atherosclerosis, most likely via complex gene-gender and gene-obesity interactions.
- Subjects :
- Male
0301 basic medicine
Candidate gene
Heredity
Physiology
Glycobiology
Cardiovascular Medicine
030204 cardiovascular system & hematology
Biochemistry
Vascular Medicine
Carotid Intima-Media Thickness
0302 clinical medicine
Genotype
Medicine and Health Sciences
Multidisciplinary
biology
Confounding
Middle Aged
Receptor, Endothelin A
PON1
Body Fluids
Genetic Mapping
Blood
C-Reactive Protein
Physiological Parameters
Cardiovascular Diseases
cardiovascular system
Medicine
Female
Independent Living
Anatomy
Research Article
medicine.medical_specialty
Science
Variant Genotypes
Single-nucleotide polymorphism
Polymorphism, Single Nucleotide
Blood Plasma
Molecular Genetics
03 medical and health sciences
Internal medicine
Genetics
medicine
Humans
SNP
Obesity
Molecular Biology
Alleles
Glycoproteins
Aryldialkylphosphatase
business.industry
Body Weight
Paraoxonase
Biology and Life Sciences
Fibrinogen
Atherosclerosis
030104 developmental biology
Endocrinology
Intima-media thickness
Genetic Loci
biology.protein
business
Subjects
Details
- ISSN :
- 19326203
- Volume :
- 15
- Database :
- OpenAIRE
- Journal :
- PLOS ONE
- Accession number :
- edsair.doi.dedup.....c33db6099dc0ad01c616165867f0c738