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Network Pharmacology Analysis of the Identification of Phytochemicals and Therapeutic Mechanisms of Paeoniae Radix Alba for the Treatment of Asthma
- Source :
- Journal of Immunology Research, Vol 2021 (2021), Journal of Immunology Research
- Publication Year :
- 2021
- Publisher :
- Hindawi Limited, 2021.
-
Abstract
- Background. Paeoniae Radix Alba (PRA), the root of the plant Paeonia lactiflora Pall., has been suggested to play an important role for the treatment of asthma. A biochemical understanding of the clinical effects of Paeoniae Radix Alba is needed. Here, we explore the phytochemicals and therapeutic mechanisms via a systematic and comprehensive network pharmacology analysis. Methods. Through TCMSP, PubChem, GeneCards database, and SwissTargetPrediction online tools, potential targets of active ingredients from PRA for the treatment of asthma were obtained. Cytoscape 3.7.2 was used to determine the target of active ingredients of PRA. Target protein interaction (PPI) network was constructed through the STRING database. The Gene Ontology (GO) biological process and Kyoto Encyclopedia of Genes and Genes (KEGG) pathway enrichment analysis were analyzed through the biological information annotation database (DAVID). Results. Our results indicate that PRA contains 21 candidate active ingredients with the potential to treat asthma. The enrichment analysis of GO and KEGG pathways found that the treatment of asthma by PRA may be related to the process of TNF (tumor necrosis factor) release, which can regulate and inhibit multiple signaling pathways such as ceramide signaling. Conclusions. Our work provides a phytochemical basis and therapeutic mechanisms of PRA for the treatment of asthma, which provides new insights on further research on PRA.
- Subjects :
- Article Subject
Databases, Pharmaceutical
Phytochemicals
Immunology
Computational biology
Network Pharmacology
Biology
Paeonia
GeneCards
Paeoniae Radix
medicine
Immunology and Allergy
Gene Regulatory Networks
Anti-Asthmatic Agents
KEGG
Asthma
Plant Extracts
Cheminformatics
General Medicine
RC581-607
medicine.disease
Gene Expression Regulation
Phytochemical
Identification (biology)
Disease Susceptibility
Target protein
Immunologic diseases. Allergy
Biomarkers
PubChem
Research Article
Drugs, Chinese Herbal
Subjects
Details
- ISSN :
- 23147156 and 23148861
- Volume :
- 2021
- Database :
- OpenAIRE
- Journal :
- Journal of Immunology Research
- Accession number :
- edsair.doi.dedup.....c3444529b7ef008ca7bede4eec6f8bb1