Characterizing Gas Exchange Physiology in Healthy Young Electronic-Cigarette Users with Hyperpolarized 129Xe MRI: A Pilot Study

Mu He,1 Kun Qing,2,3 Nicholas J Tustison,2 Zach Beaulac,4 Tabitha W King,5 Thomas B Huff,5 Mikell Paige,4 Kranthikiran Earasi,1 Roselove Nunoo-Asare,1 Sarah Struchen,2 Marie Burdick,1 Zhimin Zhang,1 Alan Ropp,2 Grady W Miller,2 James T Patrie,6 Jaime F Mata,2 John P Mugler 3rd,2 Yun Michael Shim1,2 1Department of Medicine, Division of Pulmonary and Critical Care, University of Virginia, Charlottesville, VA, USA; 2Department of Radiology & Medical Imaging, University of Virginia, Charlottesville, VA, USA; 3Radiation Oncology, Cancer Institute of New Jersey, Rutgers University, New Brunswick, NJ, USA; 4Department of Chemistry, George Mason University, Fairfax, VA, USA; 5Shared Research Instrumentation Facility, George Mason University, Manassas, VA, USA; 6School of Public Health, University of Virginia, Charlottesville, VA, USACorrespondence: Yun Michael ShimDepartment of Medicine, Division of Pulmonary and Critical Care, University of Virginia, PO Box 800546, Charlottesville, VA, 22908-0546, USAEmail yss6n@virginia.edu