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Genetics, Immunity and Nutrition Boost the Switching from NASH to HCC
- Source :
- Biomedicines, Biomedicines, Vol 9, Iss 1524, p 1524 (2021)
- Publication Year :
- 2021
- Publisher :
- MDPI, 2021.
-
Abstract
- Nonalcoholic fatty liver disease (NAFLD) is the leading contributor to the global burden of chronic liver diseases. The phenotypic umbrella of NAFLD spans from simple and reversible steatosis to nonalcoholic steatohepatitis (NASH), which may worsen into cirrhosis and hepatocellular carcinoma (HCC). Notwithstanding, HCC may develop also in the absence of advanced fibrosis, causing a delayed time in diagnosis as a consequence of the lack of HCC screening in these patients. The precise event cascade that may precipitate NASH into HCC is intricate and it entails diverse triggers, encompassing exaggerated immune response, endoplasmic reticulum (ER) and oxidative stress, organelle derangement and DNA aberrancies. All these events may be accelerated by both genetic and environmental factors. On one side, common and rare inherited variations that affect hepatic lipid remodeling, immune microenvironment and cell survival may boost the switching from steatohepatitis to liver cancer, on the other, diet-induced dysbiosis as well as nutritional and behavioral habits may furtherly precipitate tumor onset. Therefore, dietary and lifestyle interventions aimed to restore patients’ health contribute to counteract NASH progression towards HCC. Even more, the combination of therapeutic strategies with dietary advice may maximize benefits, with the pursuit to improve liver function and prolong survival.
- Subjects :
- Cirrhosis
QH301-705.5
business.industry
NASH
Medicine (miscellaneous)
Review
heritability
medicine.disease
Bioinformatics
General Biochemistry, Genetics and Molecular Biology
digestive system diseases
nutrition
Hepatocellular carcinoma
NAFLD
Nonalcoholic fatty liver disease
medicine
Liver function
Biology (General)
Steatohepatitis
Steatosis
HCC
Liver cancer
business
Dysbiosis
Subjects
Details
- Language :
- English
- ISSN :
- 22279059
- Volume :
- 9
- Issue :
- 11
- Database :
- OpenAIRE
- Journal :
- Biomedicines
- Accession number :
- edsair.doi.dedup.....c3566fa1dfe55e629749ac8ec6d9ae5d