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The Effect of the Thermosensitive Biodegradable PLGA–PEG–PLGA Copolymer on the Rheological, Structural and Mechanical Properties of Thixotropic Self-Hardening Tricalcium Phosphate Cement

Authors :
Matej Dzurov
Marek Zboncak
Lucy Vojtová
Milan Krtička
Petr Polacek
Klara Castkova
Lenka Michlovská
Edgar B. Montufar
Veronika Pavlinakova
Kristyna Valova
Martin Trunec
Vera Lukasova
Michala Rampichová
Maria-Pau Ginebra
Tomas Suchy
Radek Sedlacek
Universitat Politècnica de Catalunya. Departament de Ciència dels Materials i Enginyeria Metal·lúrgica
Universitat Politècnica de Catalunya. BBT - Biomaterials, Biomecànica i Enginyeria de Teixits
Vysoké učení technické v Brně
České vysoké učení technické v Praze
Fakultní nemocnice Brno
Akademie věd České republiky
Source :
International Journal of Molecular Sciences, Volume 20, Issue 2, International Journal of Molecular Sciences, Vol 20, Iss 2, p 391 (2019), UPCommons. Portal del coneixement obert de la UPC, Universitat Politècnica de Catalunya (UPC), International Journal of Molecular Sciences. 2019, vol. 20, issue 2, p. 1-21., Recercat. Dipósit de la Recerca de Catalunya, instname
Publication Year :
2019
Publisher :
Multidisciplinary Digital Publishing Institute, 2019.

Abstract

The current limitations of calcium phosphate cements (CPCs) used in the field of bone regeneration consist of their brittleness, low injectability, disintegration in body fluids and low biodegradability. Moreover, no method is currently available to measure the setting time of CPCs in correlation with the evolution of the setting reaction. The study proposes that it is possible to improve and tune the properties of CPCs via the addition of a thermosensitive, biodegradable, thixotropic copolymer based on poly(lactic acid), poly(glycolic acid) and poly(ethylene glycol) (PLGA&ndash<br />PEG&ndash<br />PLGA) which undergoes gelation under physiological conditions. The setting times of alpha-tricalcium phosphate (&alpha<br />TCP) mixed with aqueous solutions of PLGA&ndash<br />PLGA determined by means of time-sweep curves revealed a lag phase during the dissolution of the &alpha<br />TCP particles. The magnitude of the storage modulus at lag phase depends on the liquid to powder ratio, the copolymer concentration and temperature. A sharp increase in the storage modulus was observed at the time of the precipitation of calcium deficient hydroxyapatite (CDHA) crystals, representing the loss of paste workability. The PLGA&ndash<br />PLGA copolymer demonstrates the desired pseudoplastic rheological behaviour with a small decrease in shear stress and the rapid recovery of the viscous state once the shear is removed, thus preventing CPC phase separation and providing good cohesion. Preliminary cytocompatibility tests performed on human mesenchymal stem cells proved the suitability of the novel copolymer/&alpha<br />TCP for the purposes of mini-invasive surgery.

Details

Language :
English
ISSN :
14220067
Database :
OpenAIRE
Journal :
International Journal of Molecular Sciences
Accession number :
edsair.doi.dedup.....c3781ee33f6d1d14515b3d5f553c0fbc
Full Text :
https://doi.org/10.3390/ijms20020391