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High Prevalence of Alpha- and Beta-Thalassemia in the Kadazandusuns in East Malaysia: Challenges in Providing Effective Health Care for an Indigenous Group
- Source :
- Journal of Biomedicine and Biotechnology, Journal of Biomedicine and Biotechnology, Vol 2010 (2010)
- Publication Year :
- 2010
- Publisher :
- Hindawi Limited, 2010.
-
Abstract
- Thalassemia can lead to severe transfusion-dependent anemia, and it is the most common genetic disorder in Malaysia. This paper aims to determine the prevalence of thalassemia in the Kadazandusuns, the largest indigenous group in Sabah, East Malaysia.α- andβ-thalassemia were confirmed in 33.6% and 12.8%, of the individuals studied respectively. The high prevalence ofα- andβ-thalassemia in the Kadazandusuns indicates that thalassemia screening, genetic counseling, and prenatal diagnosis should be included as part of their healthcare system. This preliminary paper serves as a baseline for further investigations into the health and genetic defects of the major indigenous population in Sabah, East Malaysia.
- Subjects :
- congenital, hereditary, and neonatal diseases and abnormalities
Pediatrics
medicine.medical_specialty
Article Subject
lcsh:Biotechnology
Health, Toxicology and Mutagenesis
Genetic counseling
Thalassemia
Population
Prevalence
lcsh:Medicine
Prenatal diagnosis
Comorbidity
Alpha-thalassemia
Risk Assessment
Indigenous
Population Groups
alpha-Thalassemia
Risk Factors
lcsh:TP248.13-248.65
hemic and lymphatic diseases
Environmental health
Genetics
medicine
Humans
education
Molecular Biology
education.field_of_study
business.industry
lcsh:R
beta-Thalassemia
Malaysia
Beta thalassemia
General Medicine
medicine.disease
Molecular Medicine
business
Research Article
Biotechnology
Subjects
Details
- ISSN :
- 11107251 and 11107243
- Volume :
- 2010
- Database :
- OpenAIRE
- Journal :
- Journal of Biomedicine and Biotechnology
- Accession number :
- edsair.doi.dedup.....c389bd98ef008a411daf057379506d02