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Relationship of the lung microbiome with PD-L1 expression and immunotherapy response in lung cancer
Relationship of the lung microbiome with PD-L1 expression and immunotherapy response in lung cancer
- Source :
- Respiratory Research, Vol 22, Iss 1, Pp 1-10 (2021), Respiratory Research
- Publication Year :
- 2021
- Publisher :
- BMC, 2021.
-
Abstract
- Background Lung cancer is the primary cause of cancer-related deaths worldwide. The human lung serves as a niche to a unique and dynamic bacterial community that is related to the development of multiple diseases. Here, we investigated the differences in the lung microbiomes of patients with lung cancer. Methods 16S rRNA sequencing was performed to evaluate the respiratory tract microbiome present in the bronchoalveolar lavage fluid. Patients were stratified based on programmed death-ligand 1 (PD-L1) expression levels and immunotherapy responses. Results In total, 84 patients were prospectively analyzed, of which 59 showed low (Veillonella dispar was dominant in the high-PD-L1 group; the population of Neisseria was significantly higher in the low-PD-L1 group than in the high-PD-L1 group. In the immunotherapy responder group, V. dispar was dominant, while Haemophilus influenzae and Neisseria perflava were dominant in the non-responder group. Conclusion The abundances of Neisseria and V. dispar differed significantly in relation to PD-L1 expression levels and immunotherapy responses.
- Subjects :
- Male
Lung Neoplasms
RC705-779
Research
Microbiota
Middle Aged
Human microbiome
B7-H1 Antigen
Gene Expression Regulation, Neoplastic
Diseases of the respiratory system
Antineoplastic Agents, Immunological
Carcinoma, Non-Small-Cell Lung
PD-L1 expression levels
Biomarkers, Tumor
Humans
Female
Immunotherapy
Prospective Studies
Lung cancer
Lung
Aged
Taxonomy
Subjects
Details
- Language :
- English
- Volume :
- 22
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Respiratory Research
- Accession number :
- edsair.doi.dedup.....c38f0e9fbcd40f8ab27469a637e4cb08