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Relationship of the lung microbiome with PD-L1 expression and immunotherapy response in lung cancer

Relationship of the lung microbiome with PD-L1 expression and immunotherapy response in lung cancer

Authors :
Hye Jin Jang
Ji Yeon Choi
Kangjoon Kim
Seung Hyun Yong
Yeon Wook Kim
Song Yee Kim
Eun Young Kim
Ji Ye Jung
Young Ae Kang
Moo Suk Park
Young Sam Kim
Young-Jae Cho
Sang Hoon Lee
Source :
Respiratory Research, Vol 22, Iss 1, Pp 1-10 (2021), Respiratory Research
Publication Year :
2021
Publisher :
BMC, 2021.

Abstract

Background Lung cancer is the primary cause of cancer-related deaths worldwide. The human lung serves as a niche to a unique and dynamic bacterial community that is related to the development of multiple diseases. Here, we investigated the differences in the lung microbiomes of patients with lung cancer. Methods 16S rRNA sequencing was performed to evaluate the respiratory tract microbiome present in the bronchoalveolar lavage fluid. Patients were stratified based on programmed death-ligand 1 (PD-L1) expression levels and immunotherapy responses. Results In total, 84 patients were prospectively analyzed, of which 59 showed low (Veillonella dispar was dominant in the high-PD-L1 group; the population of Neisseria was significantly higher in the low-PD-L1 group than in the high-PD-L1 group. In the immunotherapy responder group, V. dispar was dominant, while Haemophilus influenzae and Neisseria perflava were dominant in the non-responder group. Conclusion The abundances of Neisseria and V. dispar differed significantly in relation to PD-L1 expression levels and immunotherapy responses.

Details

Language :
English
Volume :
22
Issue :
1
Database :
OpenAIRE
Journal :
Respiratory Research
Accession number :
edsair.doi.dedup.....c38f0e9fbcd40f8ab27469a637e4cb08