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Cross-cancer genome-wide analysis of lung, ovary, breast, prostate and colorectal cancer reveals novel pleiotropic associations
- Source :
- Cancer Res. 76, 5103-5114 (2016), Cancer Research, 76(17), 5103. American Association for Cancer Research Inc., CANCER RESEARCH, Fehringer, G, Kraft, P, Pharoah, P D, Eeles, R A, Chatterjee, N, Schumacher, F R, Schildkraut, J M, Lindström, S, Brennan, P, Bickeböller, H, Houlston, R S, Landi, M T, Caporaso, N, Risch, A, Amin Al Olama, A, Berndt, S I, Giovannucci, E L, Grönberg, H, Kote-Jarai, Z, Ma, J, Muir, K, Stampfer, M J, Stevens, V L, Wiklund, F, Willett, W C, Goode, E L, Permuth, J B, Risch, H A, Reid, B M, Bezieau, S, Brenner, H, Chan, A T, Chang-Claude, J, Hudson, T J, Kocarnik, J K, Newcomb, P A, Schoen, R E, Slattery, M L, White, E, Adank, M A, Ahsan, H, Aittomäki, K, Baglietto, L, Blomquist, C, Canzian, F, Czene, K, Dos-Santos-Silva, I, Eliassen, A H & Figueroa, J D & Flesch-Janys, D 2016, ' Cross-Cancer Genome-Wide Analysis of Lung, Ovary, Breast, Prostate, and Colorectal Cancer Reveals Novel Pleiotropic Associations ', Cancer Research, vol. 76, no. 17 . https://doi.org/10.1158/0008-5472.CAN-15-2980, Cancer Research, 76(17), 5103-5114. American Association for Cancer Research Inc., Cancer Research, 76(17), 5103-5114. AMER ASSOC CANCER RESEARCH
- Publication Year :
- 2016
- Publisher :
- Amer Assoc Cancer Research, 2016.
-
Abstract
- Identifying genetic variants with pleiotropic associations can uncover common pathways influencing multiple cancers. We took a two-stage approach to conduct genome-wide association studies for lung, ovary, breast, prostate, and colorectal cancer from the GAME-ON/GECCO Network (61,851 cases, 61,820 controls) to identify pleiotropic loci. Findings were replicated in independent association studies (55,789 cases, 330,490 controls). We identified a novel pleiotropic association at 1q22 involving breast and lung squamous cell carcinoma, with eQTL analysis showing an association with ADAM15/THBS3 gene expression in lung. We also identified a known breast cancer locus CASP8/ALS2CR12 associated with prostate cancer, a known cancer locus at CDKN2B-AS1 with different variants associated with lung adenocarcinoma and prostate cancer, and confirmed the associations of a breast BRCA2 locus with lung and serous ovarian cancer. This is the largest study to date examining pleiotropy across multiple cancer-associated loci, identifying common mechanisms of cancer development and progression. Cancer Res; 76(17); 5103–14. ©2016 AACR.
- Subjects :
- 0301 basic medicine
Oncology
Male
medicine.medical_specialty
Cancer Research
Lung Neoplasms
SUSCEPTIBILITY LOCI
Genotype
IDENTIFIES 2
Colorectal cancer
Locus (genetics)
Genome-wide association study
Breast Neoplasms
Article
03 medical and health sciences
Prostate cancer
AFRICAN ANCESTRY
Breast cancer
SDG 3 - Good Health and Well-being
Internal medicine
medicine
Journal Article
AGGRESSIVE PROSTATE
Humans
GENETIC POLYMORPHISMS
Lung cancer
METAANALYSIS
Ovarian Neoplasms
business.industry
COMMON VARIANTS
Prostatic Neoplasms
CELL CARCINOMA
medicine.disease
RISK LOCI
3. Good health
030104 developmental biology
Expression quantitative trait loci
Adenocarcinoma
Female
business
Colorectal Neoplasms
GASTRIC-CANCER
Genome-Wide Association Study
Subjects
Details
- Language :
- English
- ISSN :
- 00085472
- Database :
- OpenAIRE
- Journal :
- Cancer Res. 76, 5103-5114 (2016), Cancer Research, 76(17), 5103. American Association for Cancer Research Inc., CANCER RESEARCH, Fehringer, G, Kraft, P, Pharoah, P D, Eeles, R A, Chatterjee, N, Schumacher, F R, Schildkraut, J M, Lindström, S, Brennan, P, Bickeböller, H, Houlston, R S, Landi, M T, Caporaso, N, Risch, A, Amin Al Olama, A, Berndt, S I, Giovannucci, E L, Grönberg, H, Kote-Jarai, Z, Ma, J, Muir, K, Stampfer, M J, Stevens, V L, Wiklund, F, Willett, W C, Goode, E L, Permuth, J B, Risch, H A, Reid, B M, Bezieau, S, Brenner, H, Chan, A T, Chang-Claude, J, Hudson, T J, Kocarnik, J K, Newcomb, P A, Schoen, R E, Slattery, M L, White, E, Adank, M A, Ahsan, H, Aittomäki, K, Baglietto, L, Blomquist, C, Canzian, F, Czene, K, Dos-Santos-Silva, I, Eliassen, A H & Figueroa, J D & Flesch-Janys, D 2016, ' Cross-Cancer Genome-Wide Analysis of Lung, Ovary, Breast, Prostate, and Colorectal Cancer Reveals Novel Pleiotropic Associations ', Cancer Research, vol. 76, no. 17 . https://doi.org/10.1158/0008-5472.CAN-15-2980, Cancer Research, 76(17), 5103-5114. American Association for Cancer Research Inc., Cancer Research, 76(17), 5103-5114. AMER ASSOC CANCER RESEARCH
- Accession number :
- edsair.doi.dedup.....c38f1afcf35625c98403ee19d5ca72e8