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Genetic characterization of Chikungunya virus in the Central African Republic
- Source :
- Infection, Genetics and Evolution, Infection, Genetics and Evolution, 2015, 33, pp.25-31. ⟨10.1016/j.meegid.2015.04.006⟩, Infection, Genetics and Evolution, Elsevier, 2015, 33, pp.25-31. ⟨10.1016/j.meegid.2015.04.006⟩
- Publication Year :
- 2015
- Publisher :
- Elsevier BV, 2015.
-
Abstract
- International audience; Chikungunya virus (CHIKV) is an alphavirus transmitted by the bite of mosquito vectors. Over the past 10 years, the virus has gained mutations that enhance its transmissibility by the Aedes albopictus vector, resulting in massive outbreaks in the Indian Ocean, Asia and Central Africa. Recent introduction of competent A. albopictus vectors into the Central African Republic (CAR) pose a threat of a Chikungunya fever (CHIKF) epidemic in this region. We undertook this study to assess the genetic diversity and background of CHIKV strains isolated in the CAR between 1975 and 1984 and also to estimate the ability of local strains to adapt to A. albopictus. Our results suggest that, local CHIKV strains have a genetic background compatible with quick adaptation to A. albopictus, as previously observed in other Central African countries. Intense surveillance of the human and vector populations is necessary to prevent or anticipate the emergence of a massive CHIKF epidemic in the CAR.
- Subjects :
- MESH: Sequence Analysis, DNA
MESH: Geography
[SDV]Life Sciences [q-bio]
viruses
MESH: Chikungunya Fever
medicine.disease_cause
MESH: Animals
MESH: Genetic Variation
Chikungunya
MESH: Phylogeny
Phylogeny
Geography
biology
virus diseases
3. Good health
Central African Republic
Infectious Diseases
MESH: Central African Republic
Population Surveillance
[SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology
Chikungunya virus
Microbiology (medical)
Aedes albopictus
MESH: Insect Vectors
Alphavirus
Microbiology
Virus
MESH: Population Surveillance
Viral Proteins
Genetics
medicine
Animals
Humans
Genetic variability
Molecular Biology
Ecology, Evolution, Behavior and Systematics
Genetic diversity
MESH: Humans
fungi
Genetic Variation
Outbreak
MESH: Chikungunya virus
Sequence Analysis, DNA
biology.organism_classification
MESH: Viral Proteins
Virology
Insect Vectors
Vector (epidemiology)
Chikungunya Fever
Subjects
Details
- ISSN :
- 15671348 and 15677257
- Volume :
- 33
- Database :
- OpenAIRE
- Journal :
- Infection, Genetics and Evolution
- Accession number :
- edsair.doi.dedup.....c3914c5990215aaf55a920a8d1b32f06