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Kidney Biopsy in Patients with Cancer along the Last Decade: A Multicenter Study
- Source :
- Scientia, Journal of Clinical Medicine; Volume 11; Issue 10; Pages: 2915, Dipòsit Digital de la UB, Universidad de Barcelona
- Publication Year :
- 2022
- Publisher :
- MDPI, 2022.
-
Abstract
- Kidney biopsy; Renal pathology; Solid organ neoplasm Biòpsia renal; Patologia renal; Neoplàsia d'òrgans sòlids Biopsia renal; Patología renal; Neoplasia de órganos sólidos Background: Currently, following the new advances in cancer treatments and the increasing prevalence of kidney disease in the population, more kidney biopsies are being performed. The aim of our study is to analyze clinical and histological characteristics of patients with active solid organ malignancy who underwent kidney biopsy. This is a multi-center collaborative retrospective study supported by groups GLOSEN/Onconephrology from the Spanish Society of Nephrology. Clinical, demographical and histological data were collected. Results: A total of 148 patients with cancer who underwent a kidney biopsy from 12 hospitals were included. 64.3% men and mean age of 66.9 years old. The indications for biopsy were acute renal injury (67.1%), proteinuria (17.1%), exacerbated chronic kidney disease (8.2%), and chronic kidney disease (7.5%). Most frequent malignances were lung (29.1%) and abdominal (25%), with 49.7% metastatic cancer. As oncospecific treatment, 28% received chemotherapy, 29.3% immunotherapy, 19.3% specific therapies, and 2.1% conservative treatment. At the time of kidney biopsy, median creatinine was of 2.58 mg/dL [1.81–4.1 (IQ 25–75)], median urine protein-to-creatinine ratio of 700 mg/g [256–2463 (IQ 25–75)] and 53.1% presented hematuria. The most frequent renal biopsy diagnoses were: acute interstitial nephritis (39.9%), acute tubular necrosis (8.8%), IgA nephropathy (7.4%) and membranous nephropathy (6.1%). Median follow-up was 15.2 months [5.7–31.4 (IQ 25–75)]. Conclusions: There is a new trend in kidney disease and cancer patients in terms of diagnosis and treatment. Acute interstitial nephritis has established itself as the most common kidney injury in patients with cancer who underwent a kidney biopsy. Renal biopsy is a valuable tool for diagnosis, treatment, and prognosis of solid organ cancer patients with kidney damage. This work was supported by grants from Fondo de Investigación Sanitaria-FEDER, ISCIII, Río Hortega CM20/00111, PI17/00257, PI21/01292, Marató TV3 2020 421/C/2020, Marató TV3 2021 215/C/2021, RD16/0009/0030 (REDINREN), EIN2020-1123381, and RD21/0005/0016 (RICORS 2040).
- Subjects :
- Diagnosis::Diagnostic Techniques and Procedures::Clinical Laboratory Techniques::Cytological Techniques::Cytodiagnosis::Biopsy [ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT]
onconephrology
enfermedades urogenitales masculinas::enfermedades urológicas::enfermedades renales::insuficiencia renal::lesión renal aguda [ENFERMEDADES]
Biopsy
Càncer - Tractament
Solid organ neoplasm
kidney biopsy
Kidney biopsy
Renal pathology
diagnóstico::técnicas y procedimientos diagnósticos::técnicas de laboratorio clínico::técnicas citológicas::citodiagnóstico::biopsia [TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS]
Otros calificadores::/diagnóstico [Otros calificadores]
Ronyons - Biòpsia
General Medicine
Ronyons - Malalties
Onconephrology
Male Urogenital Diseases::Urologic Diseases::Kidney Diseases::Renal Insufficiency::Acute Kidney Injury [DISEASES]
Càncer de ronyó
Neoplasms [DISEASES]
neoplasias [ENFERMEDADES]
Renal cancer
renal pathology
Other subheadings::/diagnosis [Other subheadings]
solid organ neoplasm
Biòpsia
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Scientia, Journal of Clinical Medicine; Volume 11; Issue 10; Pages: 2915, Dipòsit Digital de la UB, Universidad de Barcelona
- Accession number :
- edsair.doi.dedup.....c3cb20822d3fb98fcafae8ac66ed1fa6