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Electrical conductivity-based contrast imaging for characterizing prostatic tissues: in vivo animal feasibility study
- Source :
- BMC Urology, Vol 19, Iss 1, Pp 1-8 (2019), BMC Urology
- Publication Year :
- 2019
- Publisher :
- BMC, 2019.
-
Abstract
- Background Electrical conductivity-based magnetic resonance (MR) imaging may provide unique information on tissue condition because its contrast originates from the concentration and mobility of ions in the cellular space. We imaged the conductivity of normal canine prostate in vivo and evaluated tissue contrast in terms of both the conductivity distribution and anatomical significance. Methods Five healthy laboratory beagles were used. After clipping the pelvis hair, we attached electrodes and placed each dog inside the bore of an MRI scanner. During MR scanning, we injected imaging currents into two mutually orthogonal directions between two pairs of electrodes. A multi spin echo pulse sequence was used to obtain the MR magnitude and magnetic flux density images. The projected current density algorithm was used to reconstruct the conductivity image. Results Conductivity images showed unique contrast depending on the prostatic tissues. From the conductivity distribution, conductivity was highest in the center area and lower in the order of the middle and outer areas of prostatic tissues. The middle and outer areas were, respectively, 11.2 and 25.5% lower than the center area. Considering anatomical significance, conductivity was highest in the central zone and lower in the order of the transitional and peripheral zones in all prostates. The transitional and peripheral zones were, respectively, 7.5 and 17.8% lower than the central zone. Conclusions Current conductivity-based MR imaging can differentiate prostatic tissues without using any contrast media or additional MR scans. The electrical conductivity images with unique contrast to tissue condition can provide a prior information on tissues in situ to be used for human imaging.
- Subjects :
- Male
Central Zone
Urology
media_common.quotation_subject
Central zone
Conductivity
lcsh:RC870-923
030218 nuclear medicine & medical imaging
03 medical and health sciences
0302 clinical medicine
Dogs
Magnetic resonance imaging
Electrical resistivity and conductivity
medicine
Electrical conductivity
Contrast (vision)
Animals
media_common
Peripheral zone
medicine.diagnostic_test
business.industry
Electric Conductivity
Prostate
Pulse sequence
General Medicine
lcsh:Diseases of the genitourinary system. Urology
language.human_language
Reproductive Medicine
030220 oncology & carcinogenesis
language
Spin echo
Feasibility Studies
business
Current density
Biomedical engineering
Research Article
Subjects
Details
- Language :
- English
- ISSN :
- 14712490
- Volume :
- 19
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- BMC Urology
- Accession number :
- edsair.doi.dedup.....c3e93129846eb97ad0d2f56d2ee8cff3