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Fibroblast growth factor receptor 2 promotes the proliferation, migration, and invasion of ectopic stromal cells via activation of extracellular-signal-regulated kinase signaling pathway in endometriosis

Authors :
Yuan Xu
Feng Gao
Jingyong Zhang
Pingping Cai
Dongsheng Xu
Source :
Bioengineered. 13:8360-8371
Publication Year :
2022
Publisher :
Informa UK Limited, 2022.

Abstract

Endometriosis is defined as the presence of endometrial tissues with cancer-like features in extrauterine locations. Fibroblast growth factor receptor 2 (FGFR2) is a tyrosine kinase that is involved in cancer pathogenesis. This study aimed to determine the role of FGFR2 in endometriosis. A total of 29 pairs of ectopic and eutopic endometrial tissues were collected from women with endometriosis. Endometrial tissues from women with hysteromyomas were considered as normal controls. Primary ectopic stromal cells (ESCs) were isolated from the ectopic endometrium. The role of FGFR2 in ESCs was assessed using immunohistochemistry, polymerase chain reaction, cell counting kit-8 assay, EdU staining, flow cytometry, transwell assay, and western blotting. The following signaling pathways were detected using bioinformatic analysis and confirmed

Details

ISSN :
21655987 and 21655979
Volume :
13
Database :
OpenAIRE
Journal :
Bioengineered
Accession number :
edsair.doi.dedup.....c3ff962e787b4c6bfd493a9a73515003