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Intensive Rehabilitation Enhances Lymphocyte BDNF-TrkB Signaling in Patients with Parkinson's Disease
- Publication Year :
- 2015
- Publisher :
- Sage, 2015.
-
Abstract
- Background. In a combined animal and human study, we have previously found that a 5-day treatment that enhances cortical plasticity also facilitates brain-derived neurotrophic factor (BDNF)-tyrosine receptor kinase B (TrkB) signaling and increases activated TrkB and N-methyl-d-aspartate receptor (NMDAR) association in both the cortex and the peripheral lymphocytes. Patients with Parkinson’s disease (PD), in general, show decreased cortical plasticity, as demonstrated by electrophysiological and behavioral studies. Here, we test the hypothesis that an exercise program that improves motor function and seems to slow down symptom progression can enhance BDNF-TrkB signaling in lymphocytes. Methods. A total of 16 patients with PD underwent a 4-week multidisciplinary intensive rehabilitation treatment (MIRT), which included aerobic training and physical and occupational therapy. Blood was collected before and after 2 and 4 weeks of MIRT. Lymphocytes were isolated to examine BDNF-TrkB signaling induced by incubation with recombinant human BDNF. TrkB signaling complexes, extracellular-signal-regulated kinase-2 and protein-kinase-B were immunoprecipitated; the content of immunocomplexes was determined by Western blotting. Results. After MIRT, all patients showed improvement in motor function. TrkB interaction with NMDAR and BDNF-TrkB signaling increased in peripheral lymphocytes at receptor, intracellular mediator, and downstream levels. The decrements in Unified Parkinson’s Disease Rating Scale II (UPDRSII) and total scores were significantly correlated with the increases in TrkB signaling at receptor, intracellular mediator, and NMDAR interaction levels. Conclusions. The significant correlation between reduced UPDRS scores and the changes in lymphocyte activity suggest that enhanced BDNF-TrkB signaling in lymphocyte and reduced severity of PD symptoms may be related.
- Subjects :
- 0301 basic medicine
Male
Parkinson's disease
Lymphocyte
Tropomyosin receptor kinase B
Severity of Illness Index
0302 clinical medicine
Occupational Therapy
Neurotrophic factors
80 and over
Lymphocytes
Receptor
Aged, 80 and over
musculoskeletal, neural, and ocular physiology
Rehabilitation
Long-term potentiation
Parkinson Disease
General Medicine
Middle Aged
medicine.anatomical_structure
Neurology
trkB
NMDA receptor
Female
LTP
Human
Signal Transduction
medicine.medical_specialty
Plasticity
Article
03 medical and health sciences
Internal medicine
Neuroplasticity
medicine
Receptor, trkB
Humans
Exercise
Physical Therapy Modalities
Aged
business.industry
Human, Immune system, LTP, Plasticity, Aged, Aged, 80 and over, Brain-Derived Neurotrophic Factor, Female, Follow-Up Studies, Gene Expression Regulation, Humans, Lymphocytes, Male, Middle Aged, Parkinson Disease, Receptor, trkB, Severity of Illness Index, Signal Transduction, Exercise, Occupational Therapy, Physical Therapy Modalities, Rehabilitation, Neurology, Neurology (clinical)
Brain-Derived Neurotrophic Factor
medicine.disease
030104 developmental biology
Endocrinology
Immune system
nervous system
Gene Expression Regulation
Immunology
Neurology (clinical)
business
030217 neurology & neurosurgery
Follow-Up Studies
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....c40738da9b527f0b331d5936f9fda6a8