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Markers of cholesterol metabolism as biomarkers in predicting diabetes in the Finnish Diabetes Prevention Study
- Source :
- Nutrition, Metabolism and Cardiovascular Diseases. 25:635-642
- Publication Year :
- 2015
- Publisher :
- Elsevier BV, 2015.
-
Abstract
- Background and aims We examined the effect of serum markers of cholesterol synthesis and absorption on the incidence of type 2 diabetes (T2D) in the randomized Finnish Diabetes Prevention Study (DPS). We also explored a possible interaction of ABCG8 rs4299376 on sterol levels and lifestyle intervention. Methods and results We conducted a prospective cohort study including overweight, middle-aged people with impaired glucose tolerance at baseline who participated in the randomized DPS. The primary outcome of the DPS was the diagnosis of T2D based on repeated oral glucose tolerance tests (OGTTs). After active intervention (median of four years, 1994–2001), non-T2D participants were further followed until T2D diagnosis, dropout or the end of 2009. Of these, 340 participants who had β-sitosterol, campesterol, lathosterol and desmosterol measured by gas chromatography-mass spectrometry during the active four-year follow-up and who were not using cholesterol lowering medications were analysed. Surrogate indexes of insulin sensitivity (IS) and secretion were calculated from an OGTT. In adjusted models, plant sterols during the four-year follow-up were associated with lower T2D incidence during the extended eight-year follow-up (HR for 1-SD change in β-sitosterol and campesterol: 0.76 [0.63–0.92], and 0.81 [0.67–0.99], respectively). Lathosterol levels were associated with higher T2D incidence (HR: 1.35 [1.13–1.62]). These associations, though, were not independent of IS. There was an interaction between rs4299376 and study group on β-sitosterol ( p = 0.001) and campesterol ( p = 0.004) levels during the follow-up. Conclusions Markers of low absorption and high synthesis of cholesterol were associated with the risk of developing T2D, mostly ascribed to IS.
- Subjects :
- Male
medicine.medical_specialty
endocrine system diseases
Endocrinology, Diabetes and Metabolism
Campesterol
Medicine (miscellaneous)
Lathosterol
Type 2 diabetes
Overweight
Cohort Studies
Impaired glucose tolerance
chemistry.chemical_compound
Diabetes mellitus
Internal medicine
Desmosterol
Glucose Intolerance
medicine
Humans
Prospective Studies
Prospective cohort study
Life Style
Finland
Nutrition and Dietetics
business.industry
Anticholesteremic Agents
ATP Binding Cassette Transporter, Subfamily G, Member 8
nutritional and metabolic diseases
Glucose Tolerance Test
Middle Aged
medicine.disease
Sterols
Cholesterol
Endocrinology
Diabetes Mellitus, Type 2
chemistry
ATP-Binding Cassette Transporters
Female
medicine.symptom
Cardiology and Cardiovascular Medicine
business
Biomarkers
Follow-Up Studies
Subjects
Details
- ISSN :
- 09394753
- Volume :
- 25
- Database :
- OpenAIRE
- Journal :
- Nutrition, Metabolism and Cardiovascular Diseases
- Accession number :
- edsair.doi.dedup.....c408dae32f78e2bc14597a9050a1482c