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Longitudinal Changes over 2 Years in Parotid Glands of Patients Treated with Preoperative 30-Gy Irradiation for Oral Cancer
- Source :
- Japanese Journal of Clinical Oncology. 41:503-507
- Publication Year :
- 2011
- Publisher :
- Oxford University Press (OUP), 2011.
-
Abstract
- Objective: To evaluate longitudinal changes in parotid volumes and saliva production over 2 years after 30 Gy irradiation. Methods: We retrospectively evaluated 15 assessable patients treated for advanced oral cancer. Eligibility criteria were a pathologic diagnosis of squamous cell carcinoma, preoperative radiation therapy with a total dose of 30 Gy delivered in 15 fractions, and the availability of longitudinal data of morphological assessments by computed tomography and functional assessments with the Saxon test spanning 2 years after radiation therapy. In the Saxon test, saliva production was measured by weighing a folded sterile gauze pad before and after chewing; the low-normal value is 2 g/2 min. Repeated-measures analysis of variance with Bonferroni adjustment for multiple comparisons was used to determine the longitudinal changes. Results: The normalized ipsilateral parotid volumes 2 weeks and 6-, 12- and 24 months after radiation therapy were found to be 72.5, 63.7, 66.9 and 78.1%, respectively; the normalized contralateral volumes were 69.8, 64.6, 72.2 and 82.0%, respectively. The bilateral parotid volumes were significantly decreased after radiation therapy (P , 0.01). The nadir appeared at 6 months post-radiation therapy and the volumes substantially recuperated 24 months after radiation therapy (P , 0.01). Mean saliva production before radiation therapy was 3.7 g; the longitudinal changes after radiation therapy were 31.3, 38.0, 43.3 and 69.6%, respectively. Substantial recuperation of saliva production was observed 24 months after radiation therapy (P ¼ 0.01). Conclusions: Although parotid volumes and saliva production were decreased after 30 Gy irradiation, we observed the recuperation of morphological and functional changes in the parotid glands 2 years after radiation therapy.
- Subjects :
- Male
Cancer Research
medicine.medical_specialty
Saliva
Time Factors
medicine.medical_treatment
Xerostomia
Preoperative care
stomatognathic system
Preoperative radiation
medicine
Humans
Parotid Gland
Radiology, Nuclear Medicine and imaging
Irradiation
Aged
Retrospective Studies
Aged, 80 and over
business.industry
Radiotherapy Planning, Computer-Assisted
Cancer
Organ Size
Recovery of Function
General Medicine
Middle Aged
medicine.disease
Neoadjuvant Therapy
Surgery
Parotid gland
Radiation therapy
stomatognathic diseases
medicine.anatomical_structure
Oncology
Chemotherapy, Adjuvant
Total dose
Carcinoma, Squamous Cell
Female
Mouth Neoplasms
Radiotherapy, Adjuvant
Tomography, X-Ray Computed
Nuclear medicine
business
Follow-Up Studies
Subjects
Details
- ISSN :
- 14653621 and 03682811
- Volume :
- 41
- Database :
- OpenAIRE
- Journal :
- Japanese Journal of Clinical Oncology
- Accession number :
- edsair.doi.dedup.....c40b307472437fd5ca2bfe115007ff60