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Inflammatory responses in SARS-CoV-2 associated Multisystem Inflammatory Syndrome and Kawasaki Disease in children: An observational study
- Source :
- PLoS ONE, 17(11 November):e0266336. Public Library of Science, PLoS ONE, 17(11). PUBLIC LIBRARY SCIENCE, Biesbroek, G, Kapitein, B, Kuipers, I M, Gruppen, M P, van Stijn, D, Peros, T E, van Veenendaal, M, Jansen, M H A, van der Zee, C W, van der Kuip, M, von Asmuth, E G J, Mooij, M G, den Boer, M E J, Landman, G W, van Houten, M A, Schonenberg-Meinema, D, Tutu van Furth, A M, Boele van Hensbroek, M, Scherpbier, H, van Meijgaarden, K E, Ottenhoff, T H M, Joosten, S A, Ketharanathan, N, Blink, M, Brackel, C L H, Zaaijer, H L, Hombrink, P, van den Berg, J M, Buddingh, E P & Kuijpers, T W 2022, ' Inflammatory responses in SARS-CoV-2 associated Multisystem Inflammatory Syndrome and Kawasaki Disease in children : An observational study ', PLoS ONE, vol. 17, no. 11 November, e0266336 . https://doi.org/10.1371/journal.pone.0266336, https://doi.org/10.371/journal.pone.0266336
- Publication Year :
- 2022
-
Abstract
- Multisystem Inflammatory Syndrome in Children (MIS-C) is a severe inflammatory disease in children related to SARS-CoV-2 with multisystem involvement including marked cardiac dysfunction and clinical symptoms that can resemble Kawasaki Disease (KD). We hypothesized that MIS-C and KD might have commonalities as well as unique inflammatory responses and studied these responses in both diseases. In total, fourteen children with MIS-C (n=8) and KD (n=6) were included in the period of March-June 2020. Clinical and routine blood parameters, cardiac follow-up, SARS-CoV-2-specific antibodies and CD4+ T-cell responses, and cytokine-profiles were determined in both groups. In contrast to KD patients, all MIS-C patients had positive Spike protein-specific CD3+CD4+ T-cell responses. MIS-C and KD patients displayed marked hyper-inflammation with high expression of serum cytokines, including the drug-targetable interleukin (IL)-6 and IFN-γ associated chemokines CXCL9, 10 and 11, which decreased at follow-up. No statistical differences were observed between groups. Clinical outcomes were all favourable without cardiac sequelae at 6 months follow-up. In conclusion, MIS-C and KD-patients both displayed cytokine-associated hyper-inflammation with several high levels of drug-targetable cytokines.
Details
- Language :
- English
- ISSN :
- 19326203
- Database :
- OpenAIRE
- Journal :
- PLoS ONE, 17(11 November):e0266336. Public Library of Science, PLoS ONE, 17(11). PUBLIC LIBRARY SCIENCE, Biesbroek, G, Kapitein, B, Kuipers, I M, Gruppen, M P, van Stijn, D, Peros, T E, van Veenendaal, M, Jansen, M H A, van der Zee, C W, van der Kuip, M, von Asmuth, E G J, Mooij, M G, den Boer, M E J, Landman, G W, van Houten, M A, Schonenberg-Meinema, D, Tutu van Furth, A M, Boele van Hensbroek, M, Scherpbier, H, van Meijgaarden, K E, Ottenhoff, T H M, Joosten, S A, Ketharanathan, N, Blink, M, Brackel, C L H, Zaaijer, H L, Hombrink, P, van den Berg, J M, Buddingh, E P & Kuijpers, T W 2022, ' Inflammatory responses in SARS-CoV-2 associated Multisystem Inflammatory Syndrome and Kawasaki Disease in children : An observational study ', PLoS ONE, vol. 17, no. 11 November, e0266336 . https://doi.org/10.1371/journal.pone.0266336, https://doi.org/10.371/journal.pone.0266336
- Accession number :
- edsair.doi.dedup.....c40f0100a65dd6b764ec67daa2a88933