Back to Search
Start Over
Spinal Cord Stimulation Reduces Ventricular Arrhythmias by Attenuating Reactive Gliosis and Activation of Spinal Interneurons
Spinal Cord Stimulation Reduces Ventricular Arrhythmias by Attenuating Reactive Gliosis and Activation of Spinal Interneurons
- Source :
- JACC Clin Electrophysiol
- Publication Year :
- 2021
-
Abstract
- OBJECTIVE: This study investigated spinal cord neuronal and glial cell activation during cardiac ischemia-reperfusion (IR)-triggered ventricular arrhythmias and neuromodulation therapy by spinal cord stimulation (SCS) BACKGROUND: Myocardial ischemia induces changes in cardiospinal neural networks leading to sudden cardiac death. Neuromodulation with SCS decreases cardiac sympathoexcitation; however, the molecular mechanisms remain unknown. METHODS: Yorkshire pigs (n=16) were randomized to Control, IR, or IR+SCS groups. A 4-pole SCS lead was placed in T1–T4 epidural space with stimulation for 30 mins prior to IR (50 Hz, 0.4msec duration, 90% motor threshold). Cardiac electrophysiological mapping and Ventricular Arrhythmia Score (VAS) were recorded. Immunohistochemistry of thoracic spinal sections was used to map and identify Fos-positive neuronal and glial cell types during IR with and without SCS. RESULTS: IR increased cardiac sympathoexcitation and arrhythmias (VAS = 6.2±0.9) which were attenuated in IR + SCS (VAS = 2.8±0.5, p=0.017). IR increased spinal cellular Fos expression (#Fos+ cells Control= 23±2 vs. IR=88±5, p
- Subjects :
- Myocardial ischemia
Reactive gliosis
Swine
Myocardial Ischemia
Spinal cord stimulation
Article
Random Allocation
Interneurons
medicine
Humans
Animals
cardiovascular diseases
Gliosis
Spinal Cord Stimulation
business.industry
Arrhythmias, Cardiac
Spinal cord
Neuromodulation (medicine)
Autonomic nervous system
Disease Models, Animal
medicine.anatomical_structure
nervous system
Spinal Cord
cardiovascular system
business
Cell activation
Neuroscience
Neuroglia
Subjects
Details
- ISSN :
- 24055018
- Volume :
- 7
- Issue :
- 10
- Database :
- OpenAIRE
- Journal :
- JACC. Clinical electrophysiology
- Accession number :
- edsair.doi.dedup.....c43d78d2b7bee9d19ed5be3561e0f5c4