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Spinal Cord Stimulation Reduces Ventricular Arrhythmias by Attenuating Reactive Gliosis and Activation of Spinal Interneurons

Spinal Cord Stimulation Reduces Ventricular Arrhythmias by Attenuating Reactive Gliosis and Activation of Spinal Interneurons

Authors :
Aman Mahajan
Yuki Kuwabara
Siamak Salavatian
Fei Gao
Bradley K. Taylor
Tomoki Yamaguchi
Stephanie Puig
Eevanna Lundquist
Kimberly Howard-Quijano
Source :
JACC Clin Electrophysiol
Publication Year :
2021

Abstract

OBJECTIVE: This study investigated spinal cord neuronal and glial cell activation during cardiac ischemia-reperfusion (IR)-triggered ventricular arrhythmias and neuromodulation therapy by spinal cord stimulation (SCS) BACKGROUND: Myocardial ischemia induces changes in cardiospinal neural networks leading to sudden cardiac death. Neuromodulation with SCS decreases cardiac sympathoexcitation; however, the molecular mechanisms remain unknown. METHODS: Yorkshire pigs (n=16) were randomized to Control, IR, or IR+SCS groups. A 4-pole SCS lead was placed in T1–T4 epidural space with stimulation for 30 mins prior to IR (50 Hz, 0.4msec duration, 90% motor threshold). Cardiac electrophysiological mapping and Ventricular Arrhythmia Score (VAS) were recorded. Immunohistochemistry of thoracic spinal sections was used to map and identify Fos-positive neuronal and glial cell types during IR with and without SCS. RESULTS: IR increased cardiac sympathoexcitation and arrhythmias (VAS = 6.2±0.9) which were attenuated in IR + SCS (VAS = 2.8±0.5, p=0.017). IR increased spinal cellular Fos expression (#Fos+ cells Control= 23±2 vs. IR=88±5, p

Details

ISSN :
24055018
Volume :
7
Issue :
10
Database :
OpenAIRE
Journal :
JACC. Clinical electrophysiology
Accession number :
edsair.doi.dedup.....c43d78d2b7bee9d19ed5be3561e0f5c4