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Applying time series analyses on continuous accelerometry data—A clinical example in older adults with and without cognitive impairment
- Source :
- PLoS ONE, PLOS ONE 16(5), e0251544-(2021). doi:10.1371/journal.pone.0251544, PLoS ONE, Vol 16, Iss 5, p e0251544 (2021)
- Publication Year :
- 2021
- Publisher :
- Public Library of Science, 2021.
-
Abstract
- IntroductionCurrent analysis approaches of accelerometry data use sum score measures which do not provide insight in activity patterns over 24 hours, and thus do not adequately depict circadian activity patterns. Here, we used a functional approach to analyze accelerometer data that models activity pattern and circadian rhythm. As a test case, we demonstrated its application in patients with mild cognitive impairment (MCI) and age-matched healthy older volunteers (HOV). Moreover, we assessed the impact of chronotype on distribution of activity data.MethodsData of two studies were pooled for this analysis. Following baseline cognitive assessment participants were provided with accelerometers for seven consecutive days. A function on scalar regression (FoSR) approach was used to analyze 24 hours accelerometer data. In a second step, analyses were controlled for chronotype using the German version of the morningness-eveningness questionnaire (d-MEQ).ResultsInformation on 47 HOV (mean age 66 SD 6 years) and 13 patients with MCI (mean age 69, SD 8 years) were available for this analysis. MCI patients displayed slightly higher activity in the morning hours as compared to HOV (maximum relative activity at 7:35 am: 75.6%, 95% CI 2.6 to 200.4%, p = 0.031). After controlling for d-MEQ, disturbed activity patterns were found in MCI of intermediate or evening chronotype, compared to HOV, i.e., MCI presented with higher activities in the morning hours (peak at 8:40 am: 357.6%, 95% CI 92.9 to 985.1, p < 0.001) and early afternoon hours (peak at 1:40 pm: 401.8%, 95% CI 63.9 to 1436.4, p < 0.001).DiscussionUsing a novel approach of FoSR, we found timeframes with higher activity levels in MCI patients compared to HOV which were not evident if sum scores of amount of activity were used. In addition, we found that previously described activity patterns as a function of chronotype swere altered in MCI patients, possibly indicating that changes in circadian rhythmicity in neurodegenerative disease are detectable using easy-to-administer accelerometry.Clinical TrialsEffects of Brain Stimulation During Nocturnal Sleep on Memory Consolidation in Patients With Mild Cognitive Impairments, https://clinicaltrials.gov/ct2/show/NCT01782391?term=NCT01782391&rank=1,ClinicalTrial.gov identifier: NCT01782391Effects of Brain Stimulation During a Daytime Nap on Memory Consolidation in Patients With Mild Cognitive Impairment,https://clinicaltrials.gov/ct2/show/NCT01782365?term=NCT01782365&rank=1,ClinicalTrial.gov identifier: NCT01782365
- Subjects :
- Male
epidemiology [Cognitive Dysfunction]
Physiology
Social Sciences
Audiology
Alzheimer's Disease
Diagnostic Radiology
Electronics Engineering
Medical Conditions
Accelerometry
Medicine and Health Sciences
Psychology
Morning
Cognitive Impairment
Cognitive Neurology
Radiology and Imaging
Age Factors
Cognition
Neurodegenerative Diseases
Middle Aged
Magnetic Resonance Imaging
Circadian Rhythm
Circadian Rhythms
Neurology
Medicine
Engineering and Technology
Memory consolidation
Female
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
Research Article
medicine.medical_specialty
Evening
Imaging Techniques
Science
Cognitive Neuroscience
methods [Accelerometry]
Research and Analysis Methods
Neuropsychology
Diagnostic Medicine
Mental Health and Psychiatry
medicine
Humans
Cognitive Dysfunction
ddc:610
Circadian rhythm
Neuropsychological Testing
Aged
Memory Consolidation
business.industry
Chronotype
Biology and Life Sciences
Nap
diagnosis [Cognitive Dysfunction]
Brain stimulation
Cognitive Science
Dementia
Electronics
Accelerometers
business
Physiological Processes
Sleep
Chronobiology
Neuroscience
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 16
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- PLoS ONE
- Accession number :
- edsair.doi.dedup.....c4762752a6c3619f473f113834024542