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Clinical outcomes with high-dose-rate surface mould brachytherapy for intra-oral and skin malignancies involving head and neck region
- Source :
- Journal of Contemporary Brachytherapy, Journal of Contemporary Brachytherapy, Vol 9, Iss 3, Pp 242-250 (2017)
- Publication Year :
- 2017
- Publisher :
- Termedia Sp. z.o.o., 2017.
-
Abstract
- Purpose : The literature and experience of high-dose-rate (HDR) surface mould brachytherapy (SMB) in head and neck cancer is sparse. We report our institutional experience of SMB for such tumours. Material and methods: Thirty-five patients with malignant localized early T1/T2, N0 (21 intra-oral and 14 skin) tumours treated with SMB during 2008-2014 were analyzed. Treatment was delivered using HDR 192Ir source to a median dose of 49 Gy (range, 38.5-52.5 Gy) as radical brachytherapy and 18 Gy (range, 15.5-30 Gy) as boost with 3-4 Gy/fraction twice daily using customized surface mould. Results : Median follow-up was 52 months (range, 6 to 98 months). Local control (LC) for skin tumours and intra-oral malignancies at 5 years were 92% and 76%, respectively. Five-year cause specific survival was 92%. For T1 and T2 tumours, 5 year LC was 94.2% and 68.2%, respectively. T stage (p < 0.04) and dose/fractions (p < 0.003) were the only significant prognostic factors for LC on univariate analysis. Conclusions : Surface mould brachytherapy results in excellent LC rates for skin tumours and T1 intraoral tumours when considered as radical treatment, and preferable to consider it as a boost for T2 intraoral tumours. Surface mould brachytherapy results in excellent organ and function preservation.
- Subjects :
- 0106 biological sciences
skin
medicine.medical_specialty
medicine.medical_treatment
brachytherapy
Brachytherapy
lcsh:Medicine
01 natural sciences
head and neck
03 medical and health sciences
0302 clinical medicine
Medicine
Radiology, Nuclear Medicine and imaging
Head and neck
Radical treatment
Original Paper
Univariate analysis
surface mould
business.industry
lcsh:R
Head and neck cancer
medicine.disease
Surgery
Oncology
030220 oncology & carcinogenesis
Intra oral
T-stage
business
Dose rate
Nuclear medicine
010606 plant biology & botany
Subjects
Details
- ISSN :
- 1689832X
- Volume :
- 3
- Database :
- OpenAIRE
- Journal :
- Journal of Contemporary Brachytherapy
- Accession number :
- edsair.doi.dedup.....c4896736015e44f654fada35fa8a3924