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Effects of induced hypotension on breathing pattern in halothane-anaesthetized man
- Source :
- European Journal of Clinical Investigation. 13:379-382
- Publication Year :
- 1983
- Publisher :
- Wiley, 1983.
-
Abstract
- The effects of hypotension induced by trimetaphan on ventilatory control were assessed in sixteen normal subjects under halothane anaesthesia. The breathing pattern, mouth occlusion pressures, lung mechanics, acid-base balance, and arterial blood gases were analysed before and during trimetaphan infusion. During induced hypotension, the only significant change in the ventilatory variables was an increase in the ratio of inspiratory duration to total cycle duration from 0.39 +/- 0.05 (SD) to 0.42 +/- 0.03; P less than 0.01. The average minute ventilation remained unchanged. No modification in lung mechanics was observed, but all subjects developed a slight but significant hypocapnic alkalosis: PaCO2 was reduced from 5.5 +/- 0.4 to 5.2 +/- 0.4 kPa (P less than 0.001) and pH increased from 7.34 to 7.36 (P less than 0.05), without change in standard bicarbonate concentration. Our data indicate that the reduction in sympathetic nervous system activity induced by trimetaphan infusion in spontaneously breathing man causes only a minor alveolar hyperventilation. The weak respiratory response to hypotension suggests that changing peripheral afferent activity has little influence on the typically rapid breathing pattern induced by halothane.
- Subjects :
- Adult
Male
Sympathetic nervous system
Alkalosis
Adolescent
Clinical Biochemistry
Acid–base homeostasis
Hypotension, Controlled
Biochemistry
Hyperventilation
medicine
Humans
Acid-Base Equilibrium
Chemistry
Respiration
General Medicine
Middle Aged
medicine.disease
Respiratory Function Tests
medicine.anatomical_structure
Anesthesia
Breathing
Arterial blood
Female
Halothane
medicine.symptom
Trimethaphan
Respiratory minute volume
medicine.drug
Subjects
Details
- ISSN :
- 13652362 and 00142972
- Volume :
- 13
- Database :
- OpenAIRE
- Journal :
- European Journal of Clinical Investigation
- Accession number :
- edsair.doi.dedup.....c4958a0496898fee4aef0b445fa0836f
- Full Text :
- https://doi.org/10.1111/j.1365-2362.1983.tb00117.x