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Periodontitis and inflammatory markers in transplant recipients
- Source :
- Journal of periodontology. 81(5)
- Publication Year :
- 2010
-
Abstract
- Inflammation is associated with the deterioration of solid-organ transplants. Chronic periodontitis is linked to systemic inflammation, although it is unknown whether it plays a causative or comorbid role. We hypothesized that transplant subjects have a greater prevalence of severe periodontitis, accompanied by higher levels of serum interleukin-6 (IL-6) and C-reactive protein (CRP), compared to systemically healthy subjects.We recruited 90 renal and cardiac transplant recipients and 72 age-matched controls and compared their periodontal and systemic inflammatory status.The prevalence of severe periodontitis was not statistically significantly different between transplant and control subjects. Serum IL-6 and CRP were higher in transplant subjects compared to control subjects and in subjects with severe periodontitis compared to subjects without periodontitis, but multivariate analysis showed that severe periodontitis was a significant positive predictor of serum IL-6 in the control group only. In the test group, significant predictors of systemic inflammation were age, diabetes, higher body mass index, and a cadaveric transplant donor.Despite the presence of higher levels of systemic markers of inflammation in transplant subjects with severe periodontitis compared to transplant subjects without periodontitis, periodontal parameters were not statistical predictors of systemic inflammation in this population in a multivariate model.
- Subjects :
- Male
medicine.medical_specialty
Systemic inflammation
Gastroenterology
Severe periodontitis
Organ transplantation
Body Mass Index
Diabetes Complications
Internal medicine
Periodontal Attachment Loss
Cadaver
Medicine
Humans
Periodontal Pocket
Periodontitis
biology
business.industry
Interleukin-6
C-reactive protein
Case-control study
Age Factors
Middle Aged
medicine.disease
Chronic periodontitis
Kidney Transplantation
Tissue Donors
C-Reactive Protein
Cross-Sectional Studies
Clinical attachment loss
Case-Control Studies
Immunology
Chronic Periodontitis
biology.protein
Periodontics
Heart Transplantation
Female
medicine.symptom
Inflammation Mediators
business
Gingival Hemorrhage
Immunosuppressive Agents
Subjects
Details
- ISSN :
- 19433670
- Volume :
- 81
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Journal of periodontology
- Accession number :
- edsair.doi.dedup.....c4a1884ef388bbf636c45b76f1835ed5