Back to Search Start Over

MARVEL domain containing CMTM4 affects CXCR4 trafficking

Authors :
Alexandra Bona
Michael Seifert
Roland Thünauer
Kyra Zodel
Ian J. Frew
Winfried Römer
Gerd Walz
Toma A. Yakulov
Source :
Molecular biology of the cell. 33(13)
Publication Year :
2023

Abstract

Defective zebrafish cmtm4 slowed the development of the posterior lateral line (pLL) by altering the Cxcr4b gradient across the pLL primordium (pLLP). Analysis in mammalian cells uncovered that CMTM4 interacted with CXCR4 and altered its glycosylation pattern but did not affect internalization or degradation of CXCR4.

Details

ISSN :
19394586
Volume :
33
Issue :
13
Database :
OpenAIRE
Journal :
Molecular biology of the cell
Accession number :
edsair.doi.dedup.....c4a24b728c00a4586a25ca8362115c56