The trade-off between sensitivity and specificity of clinical protocols for identification of insignificant prostate cancer

Indolent or insignificant prostate cancer (PCa) is an epidemiologically defined concept, with urologists and pathologists struggling to find the most appropriate corresponding clinicopathologic definition [1]. For almost 20 yr, Epstein’s pathologic definition of minimal PCa in a radical prostatectomy specimen has been used—that is, an organ-confined (pT2) cancer