Back to Search
Start Over
iNOS expression and biosynthesis of nitric oxide metabolites in the course of tumor growth of different histogenesis
- Source :
- Uspehi Molekulârnoj Onkologii, Vol 3, Iss 3, Pp 73-80 (2016)
- Publication Year :
- 2016
- Publisher :
- Publishing House ABV Press, 2016.
-
Abstract
- The dynamics of the production of nitric oxide (NO) metabolites: nitrites, nitrates, volatile nitrosamines and iNOS expression was studied in mice with subcutaneous transplanted, spontaneous and chemical- induced tumors. Tumor growth was accompanied by increased production of nitrites + nitrates in tumors or their release with urine that not dependent on tumor histotype. The total concentration of nitrites and nitrates in tumors reached micromolar levels characteristic of nitrosative stress. The ability of peritoneal macrophages + monocytes to generates nitrites was suppressed at the stage of intensive growth of the Lewis lung carcinoma, which may indicate a decrease in the cytotoxic properties of immune cells. The possibility of formation in the Erlich carcinoma of volative N-nitrosodimethylamine and N-nitrosodiethylamine compounds with pronounced carcinogenic properties was demonstrated. A positive expression of iNOS was revealed in some areas of lung carcinoma at all investigated time points using the immunohistochemical method. The lungs metastases were not stain or weakly stained. This may indicate selection of the cells with a low activity of iNOS migrating in the lungs.
- Subjects :
- Cancer Research
Pathology
medicine.medical_specialty
Nitric oxide
nitrites
expression of inos
chemistry.chemical_compound
Immune system
Biosynthesis
Carcinoma
medicine
transplanted tumors
nitric oxide metabolites
Pharmacology, Toxicology and Pharmaceutics (miscellaneous)
RC254-282
Genetics (clinical)
Carcinogen
Lung
nitrates
Biochemistry (medical)
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Lewis lung carcinoma
medicine.disease
Molecular biology
macrophages
medicine.anatomical_structure
spontaneous tumors
chemistry
n-nitrosamines
Immunohistochemistry
biosynthesis
chemical-induced tumors
Subjects
Details
- ISSN :
- 24133787 and 2313805X
- Volume :
- 3
- Database :
- OpenAIRE
- Journal :
- Advances in molecular oncology
- Accession number :
- edsair.doi.dedup.....c4cafeba10767abebda4860533d48ae3