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Gold-loaded nanoporous superparamagnetic nanocubes for catalytic signal amplification in detecting miRNA
- Source :
- Chemical communications (Cambridge, England). 53(58)
- Publication Year :
- 2017
-
Abstract
- This paper reports the development of a nonenzymatic, amplification-free, and sensitive platform for the detection of microRNA based on a new class of electrocatalytically active superparamagnetic gold-loaded nanoporous iron oxide nanocubes (Au@NPFe2O3NC). The assay showed an excellent detection sensitivity down to 100 fM and specificity towards the analysis of miR-21 in cell lines and tissue samples derived from patients with oesophageal squamous-cell carcinoma (ESCC).
- Subjects :
- Surface Properties
Iron oxide
Nanotechnology
02 engineering and technology
Biosensing Techniques
010402 general chemistry
01 natural sciences
Catalysis
chemistry.chemical_compound
Nanopores
Cell Line, Tumor
microRNA
Materials Chemistry
Humans
Particle Size
Magnetite Nanoparticles
Nanoporous
Chemistry
Metals and Alloys
General Chemistry
Electrochemical Techniques
021001 nanoscience & nanotechnology
0104 chemical sciences
Surfaces, Coatings and Films
Electronic, Optical and Magnetic Materials
MicroRNAs
Ceramics and Composites
Gold
0210 nano-technology
Signal amplification
Superparamagnetism
Subjects
Details
- ISSN :
- 1364548X
- Volume :
- 53
- Issue :
- 58
- Database :
- OpenAIRE
- Journal :
- Chemical communications (Cambridge, England)
- Accession number :
- edsair.doi.dedup.....c52d3e90786886f07002b2e619d13589