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Effect of dietary supplementation with omega-3 fatty acids on progression of atherosclerosis in carotid arteries
- Source :
- Cardiovascular research. 54(1)
- Publication Year :
- 2002
-
Abstract
- Objective: Omega-3 polyunsaturated fatty acids (ω-3 PUFA) from fish oil slow atherosclerosis progression in coronary arteries, as we showed in a randomized double-blind placebo-controlled clinical trial. Embedded in this trial, the present study examined the influence of 2 years of dietary supplementation with 1.65 g ω-3 PUFA per day on progression of carotid atherosclerosis in 223 patients with coronary artery disease. Methods: Coronary angiography, a comprehensive clinical examination, and intima-media thickness measurement by B-mode ultrasound of the carotid arteries (common, internal and bifurcation), were performed at the study start and study end. An expert panel visually evaluated the global change of carotid atherosclerosis on a semiquantitative scale. A second outcome measure was the change of overall mean maximum intima-media thickness. Results: One hundred and seventy-one patients completed the study. In the global change score, 38% of the patients in the fish oil group and 35% in the placebo group showed progression. Global change was not different between intervention groups. Mean maximum intima-media thickness increased by 0.07±0.13 mm and 0.05±0.11 mm in the fish oil and placebo group, respectively (mean±S.D., P =0.24). No correlation was found between the change in carotid and coronary arteries. Conclusions: In this group of selected patients with documented coronary artery disease ω-3 PUFA given for 2 years did not demonstrate an effect on slowing progression of atherosclerosis in carotid arteries as measured by ultrasound.
- Subjects :
- Carotid Artery Diseases
Male
medicine.medical_specialty
Physiology
Diet therapy
Coronary Disease
Coronary artery disease
Fish Oils
Double-Blind Method
Physiology (medical)
Internal medicine
Fatty Acids, Omega-3
medicine
Humans
Prospective Studies
Treatment Failure
Prospective cohort study
Aged
Ultrasonography
chemistry.chemical_classification
Vascular disease
business.industry
Middle Aged
Fish oil
medicine.disease
Coronary Vessels
Surgery
Coronary arteries
medicine.anatomical_structure
Carotid Arteries
Intima-media thickness
chemistry
Dietary Supplements
Cardiology
Disease Progression
Female
Cardiology and Cardiovascular Medicine
business
Tunica Intima
Polyunsaturated fatty acid
Subjects
Details
- ISSN :
- 00086363
- Volume :
- 54
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Cardiovascular research
- Accession number :
- edsair.doi.dedup.....c5333e2a9f9285db18009c5db86bdf5c