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Prefecture-level population structure of the Japanese based on SNP genotypes of 11,069 individuals
- Source :
- Journal of human genetics. 66(4)
- Publication Year :
- 2020
-
Abstract
- We analyzed genome-wide single-nucleotide polymorphism data of 11,069 Japanese individuals recruited from all 47 prefectures of Japan to clarify their genetic structure. The principal component analysis at the prefectural level enabled us to study the relationship between geographical location and genetic differentiation. The results revealed that the mainland Japanese were not genetically homogeneous, and the genetic structure could be explained mainly by the degree of Jomon ancestry and the geographical location. One of the interesting findings was that individuals in the Shikoku region (i.e., Tokushima Prefecture, Kagawa Prefecture, Ehime Prefecture, and Kochi Prefecture) were genetically close to Han Chinese. Therefore, the genetic components of immigrants from continental East Asia in the Yayoi period may have been well maintained in Shikoku. The present results will be useful for understanding the peopling of Japan, and also provide suggestions for recruiting subjects in genetic association studies.
- Subjects :
- 0301 basic medicine
Mainland China
Genetic Markers
Genotype
Population
030105 genetics & heredity
Polymorphism, Single Nucleotide
03 medical and health sciences
Asian People
Genetics
Humans
East Asia
Genetic Predisposition to Disease
education
Location
Genetics (clinical)
Genetic Association Studies
Genetic association
education.field_of_study
Genome, Human
030104 developmental biology
Geography
Genetics, Population
Genetic marker
Genetic structure
Demography
Subjects
Details
- ISSN :
- 1435232X
- Volume :
- 66
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Journal of human genetics
- Accession number :
- edsair.doi.dedup.....c5442f2124e160066c58819c14b4110f