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Longitudinal Outcomes of Patients with Single Ventricle after the Fontan Procedure
- Publication Year :
- 2017
-
Abstract
- Background Multicenter longitudinal objective data for survival into adulthood of patients who have undergone Fontan procedures are lacking. Objectives This study sought to describe transplant-free survival and explore relationships between laboratory measures of ventricular performance and functional status over time. Methods Exercise testing, echocardiography, B-type natriuretic peptide, functional health assessment, and medical history abstraction were repeated 9.4 ± 0.4 years after the Fontan Cross-Sectional Study (Fontan 1) and compared with previous values. Cox regression analysis explored risk factors for interim death or cardiac transplantation. Results From the original cohort of 546 subjects, 466 were contacted again, and 373 (80%) were enrolled at 21.2 ± 3.5 years of age. Among subjects with paired testing, the percent predicted maximum oxygen uptake decreased (69 ± 14% vs. 61 ± 16%; p Conclusions Interim transplant-free survival over 12 years in this Fontan cohort was 90% and was independent of ventricular morphology. Exercise performance decreased and was associated with worse functional health status. Future interventions might focus on preserving exercise capacity. (Relationship Between Functional Health Status and Ventricular Performance After Fontan—Pediatric Heart Network; NCT00132782)
- Subjects :
- Heart Defects, Congenital
medicine.medical_specialty
SF-36
medicine.drug_class
medicine.medical_treatment
Heart Ventricles
030204 cardiovascular system & hematology
Fontan Procedure
Article
Fontan procedure
03 medical and health sciences
0302 clinical medicine
Internal medicine
medicine
Natriuretic peptide
Humans
Medical history
030212 general & internal medicine
business.industry
Proportional hazards model
VO2 max
Transplantation
Cardiorespiratory Fitness
Cohort
Cardiology
Cardiology and Cardiovascular Medicine
business
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....c547dfa18c0e4b29428c976549fa812a