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Identification of baseline parameters associated with the inter-individual variability in cytidine deaminase serum activity, a key enzyme in the metabolism of pyrimidine analogue

Authors :
Laure-Hélène Preta
Michel Vidal
Jérôme Alexandre
Céline Narjoz
Dorota Desaulle
Ioannis Nicolis
Anatole Cessot
Emmanuel Curis
Benoit Blanchet
Audrey Thomas-Schoemann
François Goldwasser
Romain Cohen
Olivier Huillard
Aurelia Bessone
Source :
Annals of Oncology. 27:vi42
Publication Year :
2016
Publisher :
Elsevier BV, 2016.

Abstract

e14096Background: Cytidine deaminase (CDA) catabolizes gemcitabine and cytosine arabinoside and its serum activity (CDA-A) has been associated with efficacy and toxicity of both treatment. CDA is a...

Details

ISSN :
09237534
Volume :
27
Database :
OpenAIRE
Journal :
Annals of Oncology
Accession number :
edsair.doi.dedup.....c56925d7784a391f0c74049df011fc82
Full Text :
https://doi.org/10.1093/annonc/mdw363.89