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Coronary artery calcium quantification from contrast enhanced CT using gemstone spectral imaging and material decomposition
- Source :
- The international journal of cardiovascular imaging
- Publication Year :
- 2019
-
Abstract
- To explore the feasibility of coronary artery calcium (CAC) measurement from low-dose contrast enhanced coronary CT angiography (CCTA) as this may obviate the need for an unenhanced CT scan. 52 patients underwent unenhanced cardiac CT and prospectively ECG triggered contrast enhanced CCTA (Discovery HD 750, GE Healthcare, Milwaukee, WI, USA). The latter was acquired in single-source dual-energy mode [gemstone spectral imaging (GSI)]. Virtual unenhanced images were generated from GSI CCTA by monochromatic image reconstruction of 70 keV allowing selective iodine material suppression. CAC scores from virtual unenhanced CT were compared to standard unenhanced CT including a linear regression model. After iodine subtraction from the contrast enhanced CCTA the attenuation in the ascending aorta decreased significantly from 359 ± 61 to 54 ± 8 HU (P < 0.001), the latter comparing well to the value of 64 ± 55 HU found in the standard unenhanced CT (P = ns) confirming successful iodine subtraction. After introducing linear regression formula the mean values for Agatston, Volume and Mass scores of virtual unenhanced CT were 187 ± 321, 72 ± 114 mm(3), and 27 ± 46 mg/cm(3), comparing well to the values from standard unenhanced CT (187 ± 309, 72 ± 110 mm(3), and 27 ± 45 mg/cm(3)) yielding an excellent correlation (r = 0.96, r = 0.96, r = 0.92; P < 0.001). Mean estimated radiation dose revealed 0.83 ± 0.02 mSv from the unenhanced CT and 1.70 ± 0.53 mSv from the contrast enhanced CCTA. Single-source dual-energy scanning with GSI allows CAC quantification from low dose contrast enhanced CCTA by virtual iodine contrast subtraction.
- Subjects :
- Male
medicine.medical_specialty
media_common.quotation_subject
Cardiac-Gated Imaging Techniques
Contrast Media
chemistry.chemical_element
610 Medicine & health
Pilot Projects
Coronary Artery Disease
Coronary Angiography
Radiation Dosage
Iodine
Severity of Illness Index
2705 Cardiology and Cardiovascular Medicine
Electrocardiography
Predictive Value of Tests
Triiodobenzoic Acids
medicine.artery
Ascending aorta
medicine
2741 Radiology, Nuclear Medicine and Imaging
Humans
Contrast (vision)
Radiology, Nuclear Medicine and imaging
Vascular Calcification
Cardiac imaging
Aged
Retrospective Studies
media_common
medicine.diagnostic_test
business.industry
Subtraction
10181 Clinic for Nuclear Medicine
Middle Aged
Coronary Vessels
chemistry
Predictive value of tests
Linear Models
Feasibility Studies
Radiographic Image Interpretation, Computer-Assisted
Female
Radiology
Tomography
Tomography, X-Ray Computed
Cardiology and Cardiovascular Medicine
Nuclear medicine
business
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- The international journal of cardiovascular imaging
- Accession number :
- edsair.doi.dedup.....c59caf426452958f36c503cf48332257