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Comparison of the Effect of Ranibizumab and Verteporfin for Polypoidal Choroidal Vasculopathy: 12-Month LAPTOP Study Results
- Source :
- American Journal of Ophthalmology. 156:644-651.e1
- Publication Year :
- 2013
- Publisher :
- Elsevier BV, 2013.
-
Abstract
- To compare the effect of photodynamic therapy (PDT) and intravitreal ranibizumab in patients with polypoidal choroidal vasculopathy (PCV).Randomized clinical trial.Multicenter.Total of 93 patients with treatment-naïve PCV.Patients were randomized to 2 arms. Patients in the PDT arm underwent a single session of PDT with verteporfin, and patients in the ranibizumab arm received 3 monthly ranibizumab injections at baseline. Additional treatment was performed as needed in each arm.Primary outcome measurement was the proportion of patients gaining or losing more than 0.2 logarithm of minimal angle of resolution (logMAR) units from baseline. Mean change of logMAR and central retinal thickness (CRT) were also evaluated.In the PDT arm (n = 47), 17.0% achieved visual acuity gain, 55.3% had no change, and 27.7% experienced visual acuity loss. The results were 30.4%, 60.9%, and 8.7%, respectively, in the ranibizumab arm (n = 46), significantly better than the PDT arm (P = .039). In the PDT arm, mean CRT improved (366.8 ± 113.6 μm to 289.1 ± 202.3 μm, P.001), but logMAR was unchanged (0.57 ± 0.31 to 0.62 ± 0.40). The ranibizumab arm demonstrated improvement in both CRT (418.9 ± 168.6 μm to 311.2 ± 146.9 μm, P.001) and logMAR (0.48 ± 0.27 to 0.39 ± 0.26, P = .003). Mean change of logMAR was also greater in the ranibizumab arm (P = .011).Intravitreal injection of ranibizumab is more effective than PDT for treatment-naïve PCV.
- Subjects :
- Indocyanine Green
Male
medicine.medical_specialty
Porphyrins
Visual acuity
genetic structures
Visual Acuity
Angiogenesis Inhibitors
Antibodies, Monoclonal, Humanized
law.invention
chemistry.chemical_compound
Polyps
Double-Blind Method
Randomized controlled trial
law
Ranibizumab
medicine
Humans
In patient
Prospective Studies
Fluorescein Angiography
Coloring Agents
Prospective cohort study
Aged
Photosensitizing Agents
medicine.diagnostic_test
business.industry
Verteporfin
Choroid Diseases
Fluorescein angiography
eye diseases
Surgery
Ophthalmology
Treatment Outcome
Photochemotherapy
chemistry
Intravitreal Injections
Female
medicine.symptom
business
Indocyanine green
Tomography, Optical Coherence
Follow-Up Studies
medicine.drug
Subjects
Details
- ISSN :
- 00029394
- Volume :
- 156
- Database :
- OpenAIRE
- Journal :
- American Journal of Ophthalmology
- Accession number :
- edsair.doi.dedup.....c5a3ed3f2b2152430076e07ecd38a332