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Single-Chain Atomic Crystals as Extracellular Matrix-Mimicking Material with Exceptional Biocompatibility and Bioactivity
- Source :
- Nano Letters. 18:7619-7627
- Publication Year :
- 2018
- Publisher :
- American Chemical Society (ACS), 2018.
-
Abstract
- In this study, Mo3Se3- single-chain atomic crystals (SCACs) with atomically small chain diameters of ∼0.6 nm, large surface areas, and mechanical flexibility were synthesized and investigated as an extracellular matrix (ECM)-mimicking scaffold material for tissue engineering applications. The proliferation of L-929 and MC3T3-E1 cell lines increased up to 268.4 ± 24.4% and 396.2 ± 8.1%, respectively, after 48 h of culturing with Mo3Se3- SCACs. More importantly, this extremely high proliferation was observed when the cells were treated with 200 μg mL-1 of Mo3Se3- SCACs, which is above the cytotoxic concentration of most nanomaterials reported earlier. An ECM-mimicking scaffold film prepared by coating Mo3Se3- SCACs on a glass substrate enabled the cells to adhere to the surface in a highly stretched manner at the initial stage of cell adhesion. Most cells cultured on the ECM-mimicking scaffold film remained alive; in contrast, a substantial number of cells cultured on glass substrates without the Mo3Se3- SCAC coating did not survive. This work not only proves the exceptional biocompatible and bioactive characteristics of the Mo3Se3- SCACs but also suggests that, as an ECM-mimicking scaffold material, Mo3Se3- SCACs can overcome several critical limitations of most other nanomaterials.
- Subjects :
- Models, Molecular
Scaffold
Biocompatibility
Biocompatible Materials
Bioengineering
02 engineering and technology
engineering.material
010402 general chemistry
01 natural sciences
Cell Line
Nanomaterials
Extracellular matrix
Mice
Selenium
Tissue engineering
Coating
Biomimetic Materials
Cell Adhesion
Animals
General Materials Science
Cell adhesion
Cell Proliferation
Molybdenum
Tissue Engineering
Tissue Scaffolds
Chemistry
Mechanical Engineering
Substrate (chemistry)
General Chemistry
021001 nanoscience & nanotechnology
Condensed Matter Physics
Extracellular Matrix
0104 chemical sciences
Biophysics
engineering
Crystallization
0210 nano-technology
Subjects
Details
- ISSN :
- 15306992 and 15306984
- Volume :
- 18
- Database :
- OpenAIRE
- Journal :
- Nano Letters
- Accession number :
- edsair.doi.dedup.....c5aafc23753db3c7a788fe4e440bbb82