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Genome-wide association study in alopecia areata implicates both innate and adaptive immunity
- Source :
- Nature. 466:113-117
- Publication Year :
- 2010
- Publisher :
- Springer Science and Business Media LLC, 2010.
-
Abstract
- Alopecia areata (AA) is among the most highly prevalent human autoimmune diseases, leading to disfiguring hair loss due to the collapse of immune privilege of the hair follicle and subsequent autoimmune attack. The genetic basis of AA is largely unknown. We undertook a genome-wide association study (GWAS) in a sample of 1,054 cases and 3,278 controls and identified 139 single nucleotide polymorphisms that are significantly associated with AA (P
- Subjects :
- Adult
Male
Alopecia Areata
Human leukocyte antigen
Adaptive Immunity
Biology
GPI-Linked Proteins
Polymorphism, Single Nucleotide
T-Lymphocytes, Regulatory
Article
Autoimmune Diseases
Natural killer cell
Ikaros Transcription Factor
Antigens, CD
medicine
Humans
CTLA-4 Antigen
Genetic Predisposition to Disease
IL-2 receptor
Alleles
Aged
Autoimmune disease
Multidisciplinary
Qa-SNARE Proteins
Interleukin-2 Receptor alpha Subunit
Peroxiredoxins
Middle Aged
Alopecia areata
medicine.disease
Hair follicle
Acquired immune system
Immunity, Innate
medicine.anatomical_structure
Hair loss
NK Cell Lectin-Like Receptor Subfamily K
Case-Control Studies
Immunology
Intercellular Signaling Peptides and Proteins
Female
Hair Follicle
Genome-Wide Association Study
Subjects
Details
- ISSN :
- 14764687 and 00280836
- Volume :
- 466
- Database :
- OpenAIRE
- Journal :
- Nature
- Accession number :
- edsair.doi.dedup.....c5c2e3c204609be5a311f61fd310c43f