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Antinociceptive and sedative activity of Vernonia patula and predictive interactions of its phenolic compounds with the cannabinoid type 1 receptor

Authors :
Jamil A. Shilpi
Sariful Islam Howlader
Sohanur Rahaman
Veronique Seidel
Afjalus Siraj
Source :
Phytotherapy Research. 35:1069-1079
Publication Year :
2020
Publisher :
Wiley, 2020.

Abstract

When tested in the acetic acid-induced writhing and formalin-induced paw-licking tests, the ethanol extract of Vernonia patula (VP) aerial parts showed significant antinociceptive activity. In neuropharmacological tests, it also significantly delayed the onset of sleep, increased the duration of sleeping time, and significantly reduced the locomotor activity and exploratory behaviour of mice. Five phenolic compounds, namely gallic acid, vanillic acid, caffeic acid, quercetin and kaempferol, were detected in VP following HPLC-DAD analysis. The presence of these phenolic compounds in VP provides some support for the observed antinociceptive and sedative effects. A computational study was performed to predict the binding affinity of gallic acid, vanillic acid, caffeic acid, quercetin and kaempferol towards the cannabinoid type 1 (CB1) receptor. Caffeic and vanillic acid showed the highest probable ligand efficiency indices towards the CB1 target. Vanillic acid displayed the best blood brain barrier penetration prediction score. These findings provide some evidence for the traditional use of VP to treat pain.

Details

ISSN :
10991573 and 0951418X
Volume :
35
Database :
OpenAIRE
Journal :
Phytotherapy Research
Accession number :
edsair.doi.dedup.....c60ac6a6d80549d43577dc40e2502f95
Full Text :
https://doi.org/10.1002/ptr.6876