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Anti-glioma Activity of Dapsone and Its Enhancement by Synthetic Chemical Modification
- Source :
- Neurochemical Research. 42:3382-3389
- Publication Year :
- 2017
- Publisher :
- Springer Science and Business Media LLC, 2017.
-
Abstract
- The sulfone dapsone is an old antibiotic used for the treatment of mycobacterial and protozoal infections. We postulated before that dapsone might possess biological activity exceeding its anti-infectious properties and that it could potentially be repurposed for the treatment of glioma. To test this hypothesis, we treated established and primary cultured glioma cells with dapsone or several dapsone analogues which we previously synthesized (D2-D5) and determined effects on proliferation, anchorage-independent growth and migration. While dapsone and its synthetic analogues D2-D5 displayed only modest anti-proliferative activity, important neoplastic features such as anchorage-independent growth, clonogenic survival and directed migration were significantly inhibited by dapsone treatment. Moreover, dapsone analogues D3, D4 and D5 yielded even enhanced anti-glioma activity against different pro-neoplastic features. Overall these data suggest that dapsone provides activity against glioma which can be further enhanced by molecular modifications. These compounds could potentially serve as a therapeutic adjunct to the treatment of gliomas in a repurposing approach.
- Subjects :
- 0301 basic medicine
medicine.drug_class
Antibiotics
Dapsone
Biology
Pharmacology
Leukotriene B4
Biochemistry
Sulfone
03 medical and health sciences
Cellular and Molecular Neuroscience
chemistry.chemical_compound
0302 clinical medicine
Pharmacotherapy
Glioma
medicine
Humans
Interleukin 8
Interleukin-8
Biological activity
General Medicine
medicine.disease
Receptors, Formyl Peptide
Anti-Bacterial Agents
030104 developmental biology
chemistry
030220 oncology & carcinogenesis
Cancer cell
medicine.drug
Subjects
Details
- ISSN :
- 15736903 and 03643190
- Volume :
- 42
- Database :
- OpenAIRE
- Journal :
- Neurochemical Research
- Accession number :
- edsair.doi.dedup.....c6110b31bb581925d82ad646a1f7898e
- Full Text :
- https://doi.org/10.1007/s11064-017-2378-6