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Executive resting-state network connectivity in migraine without aura
- Source :
- Cephalalgia : an international journal of headache. 32(14)
- Publication Year :
- 2012
-
Abstract
- Background: Converging neuropsychological evidence suggests that in migraine executive functions (EF) may be affected during interictal periods. Objective: To evaluate the functional connectivity of the fronto-parietal networks (FPN) known to be associated with EF, in migraine without aura (MwoA) patients, in the interictal period, in comparison to healthy controls (HC). Methods: Using resting-state functional MRI (RS-fMRI), we compared functional connectivity within the FPN in 14 patients with MwoA versus 14 sex- and age-matched HC, and assessed the correlation between functional connectivity within FPN, clinical features of MwoA patients, and EF. We used voxel-based morphometry to assess whether between-group differences in functional connectivity were dependent on structural differences. Results: Neuropsychological data revealed no significant executive dysfunction in MwoA patients. RS-fMRI showed that MwoA patients, compared to HC, had significant functional connectivity reduction within the right FPN and specifically in the middle frontal gyrus (MFG) and the dorsal anterior cingulate cortex. In addition, we found that MFG reduced connectivity was negatively correlated with the pain intensity of migraine attacks. There were no structural differences between the two groups. Conclusions: Our data suggest that, even in the absence of clinically evident EF deficits, MwoA is associated with reduced FPN functional connectivity. This study provides further insights into the complex scenario of migraine mechanisms.
- Subjects :
- Adult
Male
Migraine without Aura
Aura
Intelligence
Neuropsychological Tests
Gyrus Cinguli
Executive Function
Young Adult
Cognition
Parietal Lobe
medicine
Humans
Ictal
Prospective Studies
Migraine, executive functions, resting-state fMRI, fronto-parietal network
Resting state fMRI
business.industry
Neuropsychology
Pain Perception
General Medicine
Executive functions
medicine.disease
Magnetic Resonance Imaging
Frontal Lobe
Frontal lobe
Migraine
Case-Control Studies
Female
Neurology (clinical)
Nerve Net
business
Neuroscience
Executive dysfunction
Subjects
Details
- ISSN :
- 14682982
- Volume :
- 32
- Issue :
- 14
- Database :
- OpenAIRE
- Journal :
- Cephalalgia : an international journal of headache
- Accession number :
- edsair.doi.dedup.....c61415292111f50a90dc79833e9d6c74