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Ecotoxicity screening evaluation of selected pharmaceuticals and their transformation products towards various organisms
- Source :
- Environ Sci Pollut Res Int, Environmental Science and Pollution Research International
- Publication Year :
- 2020
- Publisher :
- Springer Science and Business Media LLC, 2020.
-
Abstract
- The intensive development of medical science has led to an increase in the availability and use of pharmaceutical products. However, nowadays, most of scientific attention has been paid to the native forms of pharmaceuticals, while the transformation products (TPs) of these substances, understood herein as metabolites, degradation products, and selected enantiomers, remain largely unexplored in terms of their characterization, presence, fate and effects within the natural environment. Therefore, the main aim of this study was to evaluate the toxicity of seven native compounds belonging to different therapeutic groups (non-steroidal anti-inflammatory drugs, opioid analgesics, beta-blockers, antibacterial and anti-epileptic drugs), along with the toxicity of their 13 most important TPs. For this purpose, an ecotoxicological test battery, consisting of five organisms of different biological organization was used. The obtained data shows that, in general, the toxicity of TPs to the tested organisms was similar or lower compared to their parent compounds. However, for example, significantly higher toxicity of the R form of ibuprofen to algae and duckweed, as well as a higher toxicity of the R form of naproxen to luminescent bacteria, was observed, proving that the risk associated with the presence of drug TPs in the environment should not be neglected. Electronic supplementary material The online version of this article (10.1007/s11356-020-08881-3) contains supplementary material, which is available to authorized users.
- Subjects :
- Drug
Health, Toxicology and Mutagenesis
media_common.quotation_subject
0208 environmental biotechnology
Ibuprofen
02 engineering and technology
Environment
010501 environmental sciences
Ecotoxicology
01 natural sciences
Naproxen
Metabolites
Araceae
Environmental Chemistry
Ecotoxicity
0105 earth and related environmental sciences
media_common
Toxicity
Chemistry
business.industry
Luminescent bacteria
Anti-Inflammatory Agents, Non-Steroidal
Correction
General Medicine
Biotests
Pollution
020801 environmental engineering
Biotechnology
Transformation (genetics)
Transformation products
Pharmaceuticals
Opioid analgesics
Medical science
business
Water Pollutants, Chemical
Research Article
Subjects
Details
- ISSN :
- 16147499 and 09441344
- Volume :
- 27
- Database :
- OpenAIRE
- Journal :
- Environmental Science and Pollution Research
- Accession number :
- edsair.doi.dedup.....c65ca0a284475cc0ce61a339719fd5e4
- Full Text :
- https://doi.org/10.1007/s11356-020-08881-3