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Basilar Artery Diameter Is an Independent Predictor of Incident Cardiovascular Events
Basilar Artery Diameter Is an Independent Predictor of Incident Cardiovascular Events
- Source :
- Arteriosclerosis, Thrombosis, and Vascular Biology. 33:2240-2244
- Publication Year :
- 2013
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2013.
-
Abstract
- Objective— Basilar arterial (BA) dolichoectasia is associated with cerebral small-vessel disease and stroke. However, the association between moderate dilation of the BA and cerebral small-vessel disease or subsequent cardiovascular events remains unclear. This study aims to clarify the factors related to BA diameter and to clarify whether the BA diameter is an independent predictor of cardiovascular events. Approach and Results— The study subjects comprised 493 outpatients with atherosclerotic risk factors. BA diameter, lacunar infarct, severity of deep white matter hyperintensities, and intracranial steno-occlusive lesions were assessed with MRI and magnetic resonance angiography. Then, we prospectively evaluated the association between BA diameter and cardiovascular events. The BA diameter ranged from 1.1 to 5.2 mm, and only 0.8% of the patients had dolichoectasia. Male sex, the presence of lacunar infarcts, the severity of deep white matter hyperintensities, the fetal-type variation of the circle of Willis, and intracranial steno-occlusive lesions were independently associated with BA diameter. In the mean follow-up of 6.0 years, 91 patients developed cardiovascular events. BA diameter was independently associated with total cardiovascular events after adjusting for age, sex, and conventional risk factors (hazard ratio, 1.55 per 1 mm increase in BA diameter; P =0.009). Conclusions— Increased BA diameter within the normal range is related to both large-vessel disease and cerebral small-vessel disease, and it could be a new predictor of cardiovascular events.
- Subjects :
- Male
medicine.medical_specialty
Pathology
Time Factors
Independent predictor
Disease-Free Survival
Magnetic resonance angiography
Japan
Predictive Value of Tests
Risk Factors
medicine.artery
Internal medicine
Vertebrobasilar Insufficiency
Basilar artery
medicine
Humans
Prospective Studies
Vertebrobasilar insufficiency
Stroke
Aged
Aged, 80 and over
medicine.diagnostic_test
business.industry
Incidence
Magnetic resonance imaging
Middle Aged
medicine.disease
Lacunar Infarcts
Cardiovascular Diseases
Basilar Artery
Disease Progression
Cardiology
Deep white matter hyperintensities
Female
Cardiology and Cardiovascular Medicine
business
Magnetic Resonance Angiography
Dilatation, Pathologic
Subjects
Details
- ISSN :
- 15244636 and 10795642
- Volume :
- 33
- Database :
- OpenAIRE
- Journal :
- Arteriosclerosis, Thrombosis, and Vascular Biology
- Accession number :
- edsair.doi.dedup.....c663d5fe08df6d894cca6a00698e4983
- Full Text :
- https://doi.org/10.1161/atvbaha.113.301467