Bedaquiline and Delamanid Combination Treatment of 5 Patients with Pulmonary Extensively Drug-Resistant Tuberculosis

Authors :: Rosella Centis
Andrey Maryandyshev
Shashank Ganatra
Zarir F Udwadia
Rohit Amale
Sonam Topgyal
Giovanni Battista Migliori
Lia D'Ambrosio
Jan-Willem C. Alffenaar
Simon Tiberi
Jai B Mullerpattan
Giovanni Sotgiu
Emanuele Pontali
Tsetan Dorji Sadutshang
Onno W. Akkerman
Microbes in Health and Disease (MHD)
Source :: Emerging Infectious Diseases, Emerging Infectious Diseases, Vol 23, Iss 10, Pp 1718-1721 (2017), Emerging Infectious Diseases, 23(10), 1718-1721. CENTERS DISEASE CONTROL & PREVENTION
Publication Year :: 2017
Publisher :: Centers for Disease Control and Prevention (CDC), 2017.
Abstract: We report the experiences of 5 patients taking bedaquiline with delamanid in combination: 1 patient was cured; 3 culture converted, with 2 continuing and 1 changing therapy; and 1 died from respiratory insufficiency. For 2 patients, QT-interval prolongation but no arrhythmias occurred. Use of this therapy is justified for patients with limited options.

Subjects :: Male
Epidemiology
Extensively Drug-Resistant Tuberculosis
Antitubercular Agents
lcsh:Medicine
delamanid
Russia
chemistry.chemical_compound
0302 clinical medicine
XDR TB
030212 general & internal medicine
Diarylquinolines
bedaquiline
bacteria
Oxazoles
biology
Dispatch
multidrug-resistant tuberculosis
Europe
TB
Infectious Diseases
Italy
tuberculosis
Tolerability
Nitroimidazoles
combination treatment
Drug Therapy, Combination
Female
Bedaquiline and Delamanid Combination Treatment of 5 Patients with Pulmonary Extensively Drug-Resistant Tuberculosis
Delamanid
Switzerland
medicine.drug
Adult
safety
Microbiology (medical)
medicine.medical_specialty
Tuberculosis
Adolescent
pulmonary
mycobacteria
effectiveness
India
MDR-TB
lcsh:Infectious and parasitic diseases
Mycobacterium tuberculosis
Young Adult
respiratory infections
03 medical and health sciences
Combined treatment
multidrug resistance
Internal medicine
medicine
Humans
lcsh:RC109-216
antimicrobial resistance
XDR-TB
tolerability
Tuberculosis, Pulmonary
business.industry
lcsh:R
the Netherlands
Extensively drug-resistant tuberculosis
medicine.disease
biology.organism_classification
United Kingdom
Surgery
030228 respiratory system
chemistry
Bedaquiline
MDR TB
business

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