Back to Search
Start Over
Brain lesion distribution criteria distinguish MS from AQP4-antibody NMOSD and MOG-antibody disease
- Source :
- Journal of neurology, neurosurgery, and psychiatry, Journal of neurology, neurosurgery, and psychiatry, 2016, 88 (2), pp.132-136. ⟨10.1136/jnnp-2016-314005⟩
- Publication Year :
- 2016
- Publisher :
- HAL CCSD, 2016.
-
Abstract
- Importance Neuromyelitis optica spectrum disorders (NMOSD) can present with very similar clinical features to multiple sclerosis (MS), but the international diagnostic imaging criteria for MS are not necessarily helpful in distinguishing these two diseases. Objective This multicentre study tested previously reported criteria of ‘(1) at least 1 lesion adjacent to the body of the lateral ventricle and in the inferior temporal lobe; or (2) the presence of a subcortical U-fibre lesion or (3) a Dawson9s finger-type lesion’ in an independent cohort of relapsing-remitting multiple sclerosis (RRMS) and AQP4-ab NMOSD patients and also assessed their value in myelin oligodendrocyte glycoprotein (MOG)-ab positive and ab-negative NMOSD. Design Brain MRI scans were anonymised and scored on the criteria by 2 of 3 independent raters. In case of disagreement, the final opinion was made by the third rater. Participants 112 patients with NMOSD (31 AQP4-ab-positive, 21 MOG-ab-positive, 16 ab-negative) or MS (44) were selected from 3 centres (Oxford, Strasbourg and Liverpool) for the presence of brain lesions. Results MRI brain lesion distribution criteria were able to distinguish RRMS with a sensitivity of 90.9% and with a specificity of 87.1% against AQP4-ab NMOSD, 95.2% against MOG-ab NMOSD and 87.5% in the heterogenous ab-negative NMOSD cohort. Over the whole NMOSD group, the specificity was 89.7%. Conclusions This study suggests that the brain MRI criteria for differentiating RRMS from NMOSD are sensitive and specific for all phenotypes.
- Subjects :
- 0301 basic medicine
Adult
Male
Pathology
medicine.medical_specialty
Multiple Sclerosis
Adolescent
Sensitivity and Specificity
Temporal lobe
Myelin oligodendrocyte glycoprotein
Lesion
Diagnosis, Differential
03 medical and health sciences
Young Adult
0302 clinical medicine
Neuroimaging
medicine
Humans
Child
Aged
Autoantibodies
Aged, 80 and over
Aquaporin 4
medicine.diagnostic_test
biology
business.industry
Multiple sclerosis
Cranial nerves
Neuromyelitis Optica
Brain
Magnetic resonance imaging
Middle Aged
medicine.disease
Magnetic Resonance Imaging
Psychiatry and Mental health
030104 developmental biology
Child, Preschool
Cohort
biology.protein
Surgery
Female
Myelin-Oligodendrocyte Glycoprotein
[SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]
Neurology (clinical)
medicine.symptom
business
030217 neurology & neurosurgery
Subjects
Details
- Language :
- English
- ISSN :
- 1468330X
- Database :
- OpenAIRE
- Journal :
- Journal of neurology, neurosurgery, and psychiatry, Journal of neurology, neurosurgery, and psychiatry, 2016, 88 (2), pp.132-136. ⟨10.1136/jnnp-2016-314005⟩
- Accession number :
- edsair.doi.dedup.....c674a405f46f6846a6bce954dd5f0f69