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Age at menarche and depressive symptoms in older Southern Chinese women: A Mendelian randomization study in the Guangzhou Biobank Cohort Study
- Source :
- Psychiatry research. 259
- Publication Year :
- 2017
-
Abstract
- To clarify the causal role of age at menarche in depressive symptoms we conducted a Mendelian randomization study using a large Southern Chinese cohort (n = 12,233). A genetic allele score was derived using stepwise regression with cross validation. Older age at menarche was not associated with geriatric depression scale score. Our findings suggest that higher rates of depression in women are likely attributable to other factors which require investigation.
- Subjects :
- 0301 basic medicine
Gerontology
Male
medicine.medical_specialty
China
Cohort Studies
03 medical and health sciences
0302 clinical medicine
Asian People
Epidemiology
Mendelian randomization
Medicine
Humans
030212 general & internal medicine
Biological Psychiatry
Depression (differential diagnoses)
Aged
Aged, 80 and over
Menarche
business.industry
Depression
Age Factors
Stepwise regression
Mendelian Randomization Analysis
Middle Aged
Psychiatry and Mental health
030104 developmental biology
Cohort
Regression Analysis
Geriatric Depression Scale
Female
business
Cohort study
Subjects
Details
- ISSN :
- 18727123
- Volume :
- 259
- Database :
- OpenAIRE
- Journal :
- Psychiatry research
- Accession number :
- edsair.doi.dedup.....c6ba487cb29ab66710ca6b99a03d2cf5