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Baseline characteristics, management, and outcomes of 55,270 children and adolescents diagnosed with COVID-19 and 1,952,693 with influenza in France, Germany, Spain, South Korea and the United States: an international network cohort study
- Source :
- medRxiv
- Publication Year :
- 2020
- Publisher :
- Cold Spring Harbor Laboratory, 2020.
-
Abstract
- ObjectivesTo characterize the demographics, comorbidities, symptoms, in-hospital treatments, and health outcomes among children/adolescents diagnosed or hospitalized with COVID-19. Secondly, to describe health outcomes amongst children/adolescents diagnosed with previous seasonal influenza.DesignInternational network cohort.SettingReal-world data from European primary care records (France/Germany/Spain), South Korean claims and US claims and hospital databases.ParticipantsDiagnosed and/or hospitalized children/adolescents with COVID-19 at age Main outcome measuresBaseline demographics and comorbidities, symptoms, 30-day in-hospital treatments and outcomes including hospitalization, pneumonia, acute respiratory distress syndrome (ARDS), multi-system inflammatory syndrome (MIS-C), and death.ResultsA total of 55,270 children/adolescents diagnosed and 3,693 hospitalized with COVID-19 and 1,952,693 diagnosed with influenza were studied.Comorbidities including neurodevelopmental disorders, heart disease, and cancer were all more common among those hospitalized vs diagnosed with COVID-19. The most common COVID-19 symptom was fever. Dyspnea, bronchiolitis, anosmia and gastrointestinal symptoms were more common in COVID-19 than influenza.In-hospital treatments for COVID-19 included repurposed medications (Hospitalization was observed in 0.3% to 1.3% of the COVID-19 diagnosed cohort, with undetectable (NConclusionsDespite negligible fatality, complications including pneumonia, ARDS and MIS-C were more frequent in children/adolescents with COVID-19 than with influenza. Dyspnea, anosmia and gastrointestinal symptoms could help differential diagnosis. A wide range of medications were used for the inpatient management of pediatric COVID-19.What is already known on this topic?Most of the early COVID-19 studies were targeted at adult patients, and data concerning children and adolescents are limited.Clinical manifestations of COVID-19 are generally milder in the pediatric population compared with adults.Hospitalization for COVID-19 affects mostly infants, toddlers, and children with pre-existing comorbidities.What this study adds⍰This study comprehensively characterizes a large international cohort of pediatric COVID-19 patients, and almost 2 million with previous seasonal influenza across 5 countries.⍰Although uncommon, pneumonia, acute respiratory distress syndrome (ARDS) and multi-system inflammatory syndrome (MIS-C) were more frequent in children and adolescents diagnosed with COVID-19 than in those with seasonal influenza.⍰Dyspnea, bronchiolitis, anosmia and gastrointestinal symptoms were more frequent in COVID-19, and could help to differentiate pediatric COVID-19 from influenza.⍰A plethora of medications were used during the management of COVID-19 in children and adolescents, with great heterogeneity in the use of antiviral therapies as well as of adjunctive therapies.
- Subjects :
- ARDS
Pediatrics
medicine.medical_specialty
Heart disease
Anosmia
Article
Comorbidities
03 medical and health sciences
0302 clinical medicine
030225 pediatrics
medicine
Primary care records
030212 general & internal medicine
Children
business.industry
Treatments
COVID-19
Health outcomes
Claims
Hospital databases
medicine.disease
Influenza
Real-world data
3. Good health
Pneumonia
Bronchiolitis
Symptoms
Cohort
Demographics
medicine.symptom
Differential diagnosis
business
Cohort study
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- medRxiv
- Accession number :
- edsair.doi.dedup.....c6c5e91dafda8a9dfc3120e894a0a681