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Clinical characteristics and natural history of RHO-associated retinitis pigmentosa

Authors :
Gislin Dagnelie
Ralph J. Florijn
Caroline Van Cauwenbergh
Maria M. van Genderen
Alberta A H J Thiadens
Mays Talib
Nicoline E. Schalij-Delfos
Jan Wijnholds
Julie De Zaeytijd
Camiel J. F. Boon
Mary J. van Schooneveld
Caroline C W Klaver
Irina Balikova
Elfride De Baere
Marta Fiocco
Carel B. Hoyng
Magda A. Meester-Smoor
Xuan Thanh An Nguyen
Arthur A.B. Bergen
L. Ingeborgh van den Born
Jacoline B. ten Brink
Bart P. Leroy
Ophthalmology
Epidemiology
Human Genetics
ANS - Complex Trait Genetics
ARD - Amsterdam Reproduction and Development
Netherlands Institute for Neuroscience (NIN)
Source :
Retina-The Journal of Retinal and Vitreous Diseases, 41, 1, pp. 213-223, Retina (Philadelphia, Pa ), 41(1), 213-223, RETINA, The Journal of Retinal and Vitreous Diseases, 41(1), 213-223. LIPPINCOTT WILLIAMS & WILKINS, Retina-The Journal of Retinal and Vitreous Diseases, 41, 213-223, Retina (Philadelphia, Pa.), 41(1), 213-223. Lippincott Williams and Wilkins, Retina, 41, 213-223. Lippincott Williams & Wilkins, RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES, RETINA, The Journal of Retinal and Vitreous Diseases
Publication Year :
2021
Publisher :
LIPPINCOTT WILLIAMS & WILKINS, 2021.

Abstract

PURPOSE: To investigate the natural history of RHO-associated retinitis pigmentosa (RP). METHODS: A multicenter, medical chart review of 100 patients with autosomal dominant RHO-associated RP. RESULTS: Based on visual fields, time-to-event analysis revealed median ages of 52 and 79 years to reach low vision (central visual field

Subjects

Subjects :
0301 basic medicine
Male
Visual acuity
genetic structures
Visual Acuity
Retinal Pigment Epithelium
Sensory disorders Donders Center for Medical Neuroscience [Radboudumc 12]
chemistry.chemical_compound
0302 clinical medicine
Medicine and Health Sciences
sector retinitis pigmentosa
General Medicine
Middle Aged
Natural history
Phenotype
natural history
Female
medicine.symptom
Tomography, Optical Coherence
medicine.medical_specialty
Long term follow up
inherited retinal dystrophies
03 medical and health sciences
All institutes and research themes of the Radboud University Medical Center
Ophthalmology
retinitis pigmentosa
Retinitis pigmentosa
medicine
Electroretinography
Humans
In patient
Aged
Retrospective Studies
Surrogate endpoint
business.industry
Retinal
medicine.disease
eye diseases
Low vision
030104 developmental biology
chemistry
rhodopsin
030221 ophthalmology & optometry
sense organs
Visual Fields
business
Acute-Phase Proteins
Follow-Up Studies
Forecasting

Details

Language :
English
ISSN :
0275004X and 15392864
Database :
OpenAIRE
Journal :
Retina-The Journal of Retinal and Vitreous Diseases, 41, 1, pp. 213-223, Retina (Philadelphia, Pa ), 41(1), 213-223, RETINA, The Journal of Retinal and Vitreous Diseases, 41(1), 213-223. LIPPINCOTT WILLIAMS & WILKINS, Retina-The Journal of Retinal and Vitreous Diseases, 41, 213-223, Retina (Philadelphia, Pa.), 41(1), 213-223. Lippincott Williams and Wilkins, Retina, 41, 213-223. Lippincott Williams & Wilkins, RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES, RETINA, The Journal of Retinal and Vitreous Diseases
Accession number :
edsair.doi.dedup.....c6c86c4644c4a1c8e582729bac6e0c3d

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