A hierarchical testing procedure with a futility interim analysis and partial pooling of data based on two phase III twin studies

Authors :: Uhlmann, L
Wei, X
You, R
Gong, Y
Keefe, D
Muscianisi, E
Vandemeulebroecke, M
Source :: 65th Annual Meeting of the German Association for Medical Informatics, Biometry and Epidemiology (GMDS), Meeting of the Central European Network (CEN: German Region, Austro-Swiss Region and Polish Region) of the International Biometric Society (IBS); 20200906-20200909; Berlin; DOCAbstr. 155 /20210226/
Publication Year :: 2021
Publisher :: German Medical Science GMS Publishing House, 2021.
Abstract: Background: In the planning stage of a clinical study, several challenges need to be considered in the statistical design apart from the classical tasks (for example, the definition of the primary and secondary analysis models and the according sample size). We designed two phase III twin studies to[for full text, please go to the a.m. URL]<br />65th Annual Meeting of the German Association for Medical Informatics, Biometry and Epidemiology (GMDS), Meeting of the Central European Network (CEN: German Region, Austro-Swiss Region and Polish Region) of the International Biometric Society (IBS)

Subjects :: ddc: 610
hierarchical testing
futility analysis
pooling of data
610 Medical sciences
Medicine
phase III studies

Language :: English
Database :: OpenAIRE
Journal :: 65th Annual Meeting of the German Association for Medical Informatics, Biometry and Epidemiology (GMDS), Meeting of the Central European Network (CEN: German Region, Austro-Swiss Region and Polish Region) of the International Biometric Society (IBS); 20200906-20200909; Berlin; DOCAbstr. 155 /20210226/
Accession number :: edsair.doi.dedup.....c6d4ed703b16a814887e10b5c729de04
Full Text :: https://doi.org/10.3205/20gmds291

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